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Inhibitor of apoptosis protein Livin in bladder transitional cell carcinoma and its clinical significance


P> 0.05). This literature (13 reported basically the same. that the abnormal expression of TM1 with no obvious relationship between clinical stage and grade , suggesting that changes in TM1 expression in bladder cancer is an early event occurs ,[link widoczny dla zalogowanych], early diagnosis of bladder cancer as an important indicator of Also may be bladder cancer gene therapy to provide an effective target. As TM1 tumor suppressor mechanism, we think we should consider the following three aspects : ① TM1 and E -cadherin catenin complex a mouth connected to form Cytoskeleton, and jointly promote the adhesion between epithelial cells ,[link widoczny dla zalogowanych], maintain tissue structural integrity and polarity. and TM1 -induced cytoskeleton, in the inhibition of malignant phenotype plays an important role in the process . Once TM1 damaged or missing ,[link widoczny dla zalogowanych], can make Cell adhesion function decline or loss , leading to malignant transformation of cells . ② combination of endostatin and TM , undermining the structural integrity of actin filaments ,[link widoczny dla zalogowanych], leading to loss of function of cell movement , apoptosis , and ultimately inhibit tumor ∞. ③ Pawlak and other Shows that when the tumor occurs,[link widoczny dla zalogowanych], the Ras-MEK signaling pathway mediates the HMWTM dependent expression and localization of the change, so that in these tumors , TM1 expression down is possible. [
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