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Liu SM ammonia SASP combination of efficacy in patients with ulcerative colitis and the impact of neuroendocrine-immune network


C pathogenesis an important part. At present T-cell dysfunction can be sure that is an important factor in the pathogenesis of UC. T-lymphocytes in UC patients to render the sub-group antigen ratio between the disorder, giving rise to other inflammatory cells, cytokines and inflammatory mediators in the imbalance, immune response disorders, causing intestinal inflammation and tissue damage. Scattered in the gastrointestinal mucosa that secretes many peptides and amines in the cell, but also the distribution of peptide substances secreted in the enteric nervous system and play many physiological effects. Somatostatin is widely distributed in the gastrointestinal tract by the D-cells, can inhibit the gastrointestinal hormones, pancreatic hormones, VIP and neuropeptide release; inhibition of exocrine digestive system and gastrointestinal movement. P substance is composed of 11 amino acid peptide, can promote gastrointestinal motility,[link widoczny dla zalogowanych], increased intestinal blood flow, promote intestinal secretion, stimulation of inflammatory cells and immune cells to secrete inflammatory mediators, enzymes, cytokines and antibodies. Vasoactive intestinal peptide of 27 amino acids, widely distributed in the gastrointestinal tract,[link widoczny dla zalogowanych], can promote the secretion of the small intestine and pancreas,[link widoczny dla zalogowanych], regulate gastrointestinal sphincter, expansion of intestinal blood vessels, increase intestinal blood flow. Now commonly used drugs for the treatment of UC-amino salicylic acid, cortisol and immune inhibitor class, have poor efficacy and side effects of many of the disadvantages. Data shows that in China, SASP treatment of UC is still a major western medicine, can relieve mild to moderate disease patients, and for maintenance treatment of moderate to severe patients and as adjuvant therapy, more effective. The results show that, SASP rule of Clinical 2OO4 16 years, No. 4 UC treatment is generally considered the mechanism of inhibition of leukotrienes, prostaglandins and free radicals, interference with the synthesis of inflammatory mediators, thereby inhibiting local and systemic inflammation response; also suppress the immune cells of the immune response; can be used for anti-recurrent. Modern pharmacological studies have shown that Salvia immune regulation, anti-inflammatory anti-allergic, anti-oxidation, anti-bacterial, anti-coagulation fibrinolysis, platelet aggregation and anti-thrombosis and other broad and complex pharmacological effects _3J. UC active stage of CD, NK cells significantly decreased compared with healthy people. Information, uC directly from Th cells increased, especially in inflammatory cells led to the development of more appropriate, tissue damage _4,, which is consistent with the experimental results. SASP + Salvia After 6 weeks of treatment, patients with CD4, CD8, NK, CD4/CD8 compared with the control group no significant difference,[link widoczny dla zalogowanych], suggesting that through the influence of Salvia sAsP + T cell subsets, immune responses to the treatment effect of UC. UC active plasma sP significantly decreased compared with healthy people, plasma VIP, SS was significantly higher than healthy people. The sAsP + Salvia After 6 weeks of treatment,[link widoczny dla zalogowanych], plasma SP, VIP, SS content compared with the control group significantly different, suggesting that SASP + salvia is by influencing the level of gastrointestinal neuropeptides play a role in the treatment of UC. That, in patients with active uC disorder of T cell subsets and plasma neuropeptide levels of gastrointestinal abnormalities; treatment uc Danshen injection Time sASP combination SASP in comparison with the total effective rate is higher. Salvia injection in treating UC by the possible mechanism of T cell subsets, immune response, affecting the level of gastrointestinal neuropeptides play a role in the treatment of UC. For cytokines, inflammatory mediators, oxygen radicals, platelet aggregation and vascular injury in the UC role in the pathogenesis of UC Salvia other possible mechanisms of treatment needs further study.