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 Posted: Mon 21:16, 17 Jan 2011 Post subject: tory burch shoes Ferrous oxidase Hephaestin Progre |
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Ferrous oxidase Hephaestin Research Progress
tionmodulatecoppertoxicityinSaccharo-myceseerevisiae. JBiolChem, 2003,278:50309 ~ 50315.5ChenH,[link widoczny dla zalogowanych], AttiehZK, SuT, eta1. Hephaestinisaferroxi-dasethatmaintainspartialactivityinsex-linkedanemiamice. Blood, 2004,[link widoczny dla zalogowanych],103:3933 ~ 3939.6ChenH, SuT, AttiehZK, eta1. SystemicregulationofHephaestinandIreglrevealedinstudiesofgeneticandnu-tritionalirondeficiency. Blood, 2003,102:1893 ~ 1899.7ZollerH, TheurlI, KochRO, eta1. Duodenalcytochromebandhephaestinexpressioninpatientswithirondeficiencyandhemochromatosis. Gastroenterology, 2003,125:746 ~ 754.8ChenH, HuangG, SuT, eta1. Decreasedhe: phaestinac-tivityintheintestineofcopper-· deficientmicecausessystem-· icirondeficiency. JNutr. 2006,136:1236 ~ 1241.9KelleherSL, LonnerdalB. Zincsupplementationreducesi-ronabsorptionthroughage-· dependentchangesinsmallintes-· tineirontransporterexpressioninsucklingratpups. JNutr, 2006,136:1185 ~ 1191. DAI as a DNA sensor can activate the innate immune response to the central link in innate immunity is associated with cytoplasm and cell membrane receptors on the perception of pathogen-associated molecules. The course of infection or tissue damage, DNA is a potent activator of immune response. Previous studies showed that in addition to the cell membrane associated Toll-like receptor 9 (Tol11ikereceptor9, TLR9), but has not yet been identified in the cytoplasm of a DNA sensor can also activate the type 1 interferon (IFN) and cause other immune responses. AkinoriTakaoka and other recently reported a new DNA sensor was found that the DNA dependent activator of interferon regulatory factor (DNAdependentactivatorofIFN-regulatoryfactors,[link widoczny dla zalogowanych], DAI). The new sensor had to be identified because the biological function of DNA is unknown, once known as DLM-1 and Z-DNA binding protein 1 (ZBP1). In mouse fibroblast cells the expression of IFN inducible human DAI, can selectively enhance the DNA-mediated induction of type 1 IFN production and other innate immune-related gene expression. On the other hand, the use of cell messenger RNA in the DAI of RNA interference to inhibit the gene in DNA from various sources by the stimulation of the induction process. With double-stranded DNA binding DAI, thereby enhancing the activation of transcription factors with IRF3 and TBK1 in the Sisu histidine protein kinase activity. More importantly,[link widoczny dla zalogowanych], DAI is likely itself to be able to collect DNA-dependent manner IRF3 and TBK1. Specific signaling pathway is still unclear. Previous results show that the DAI in the DNA-mediated innate immune reaction play an important role in the study to further understand the DNA-related anti-microbial immunity and autoimmune diseases, the signal mechanism between the new point of view. (Nature,[link widoczny dla zalogowanych], 2007,448:501 ~ 505) (Feng Juan)
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