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Hydroxyapatite combined with bone marrow treatment of femoral head necrosis


Joint Core decompression of the cancellous bone implants, vascular bundle graft , free vascularized fibular graft ,[link widoczny dla zalogowanych], pedicle bone graft and so on. On this basis . Hemigou other -51 reported by core decompression and autologous bone marrow stem cells transplantation in the treatment of avascular necrosis. Its efficacy and patient lesion and staging. Meanwhile, the progenitor cells transplant success The more effective the better. However,[link widoczny dla zalogowanych], autologous bone marrow stem cell separation, culture, purification and subculture cycle is long, many confounding factors ,[link widoczny dla zalogowanych], more complicated operation . We use hydroxyapatite as a scaffold . 447 * from the bone marrow composite graft as the treatment of early osteonecrosis . Good results. Through experiments we found that serum BGP levels before and after treatment the difference was statistically significant. The results show that : in bone marrow not only contains a variety of bone growth factors . Contain both pre- osteoblasts, also has no immunity , easy access and easy operation . BGP carboxyglutamic acid protein , also known as a bone , as bone tissue in a non- collagen protein,[link widoczny dla zalogowanych], bone cells are a class of peptide substances. Therefore , BGP can be used as reflecting the activity of osteoblast -specific indicators. The results show : Core decompression combined hydroxyapatite and autologous red bone marrow before and after treatment of early femoral head necrosis , serum BGP was significantly elevated , indicating that hydroxyapatite combined with bone marrow transplantation in the osteoblast Differentiation and formation. Antagonist of the hormone on bone metabolism and bone cell line. Early aseptic necrosis of the femoral head can promote the self- repair. Core decompression surgery combined with hydroxyapatite combined with bone marrow transplantation in the treatment of early aseptic necrosis of femoral head , and promoted the proliferation of osteoblasts ; reduced osteoblasts and their precursors,[link widoczny dla zalogowanych], fatty degeneration or apoptosis and then necrosis ; further Improve the early pathological changes of femoral head necrosis , so . This method has some clinical value.