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Erythromycin treatment of external genital report of 21 cases of hemangioma


1.6 [Document code] A [Article ID] 1001-1420 (2004) 03-0180-0l common clinical genital hemangioma, treatment methods more, but each has advantages and disadvantages. According to intravenous injection or intravenous infusion of erythromycin lactobionate can cause thrombophlebitis. Principle,[link widoczny dla zalogowanych], since 1995, we have 21 cases genital hemangioma patients, local injection of erythromycin-line treatment, more effective, less side effects. Are as follows. 1 Data and methods 1.1 Clinical data of the 21 patients, 16 males and 5 females; aged 2 to 35 years old. 6 cases of capillary hemangioma, cavernous hemangioma in 12 cases, capillary hemangioma and cavernous hemangioma of mixed type in 3 cases. Hemangioma of the Ministry of 12 cases in the scrotum,[link widoczny dla zalogowanych], perineum in 5 cases, the penis body in 2 cases, the penis head in 2 cases. The smallest tumor O. 3cm × 0.3cm × 0.3cm, the largest 8cm × 6cm × 3cm. 1.2 Treatment with erythromycin lactobionate powder 0.3g, was dissolved in 3ml water for injection, that is dubbed 1O erythromycin solution, appearance is colorless and transparent liquid. Local routine disinfection with 0.5 iodophor. Capillary hemangioma in 1 of a 4 gauge needle about 2mm from the edge of the tumor into normal skin at the Si needle, piercing the tumor in vivo, into the solution of 1O to erythromycin hemangioma color white. Larger tumors can be multiple needle injections, an adult dose of no more than 1Oml,[link widoczny dla zalogowanych], 2 years of age children are usually not more than 5ml; cavernous tumors are from the edge of the needle at about 1cm, with 7 gauge needle through through normal skin in the subcutaneous tumor sneak piercing body Withdrawing after the slow injection of blood 1O erythromycin solution to the obvious tension of the tumor until the dose as before. Mixed hemangioma, refer to the above two methods. Larger tumors can be injected one week 1. Adult penis type, head type penis oral diethylstilbestrol treatment to prevent nocturnal penile erection. 2 Results of the 21 cases with 1 to 5 injections were followed up for 1 to 3 years, effective 98, treatment satisfaction, low recurrence rate. 2 cases of local swelling and pain after injection, 24 ~ 48h after natural disappeared; 1 case of nausea, vomiting, disappear naturally without treatment. However, some patients leave a flat scar or pigmentation. Xiaogan Central Hospital Urology (Xiaogan .432100). 3 Central Hospital of Plastic Surgery Xiaogan discuss the experimental studies have shown that erythromycin solution 2ml intramuscular injection with rabbit 1O back, the first three days in the area of ​​intimal pathology see obvious damage, 7d muscle cells was swelling, degeneration and necrosis; with 0.5ml of the liquid injected into the central vein of rabbit ears, see the pathology on day 3 of intimal injury, and thrombosis at 7 days showed obvious thrombosis. Animal experiments show that high concentrations of erythromycin solution directly damage blood vessel wall endothelial cells in tumors so that tumors in vivo thrombus formation, fibrosis, so that the resulting effect of blocking blood vessel tumor. The treatment for hemangioma, cavernous hemangioma, and two mixed. There was blood on the drainage branch of the cavernous and racemose hemangioma, yet with this method, taking into account soon after the drug injection into the blood circulation, causing high blood concentration, easy to cause toxic reactions. 2 patients in this group after injection of the limitations of erythromycin scrotal swelling, flushing, pain, especially in cavernous hemangioma as the most important, no treatment, 24 ~ 48h after the symptoms disappear. One case of nausea,[link widoczny dla zalogowanych], vomiting, and pain may be caused by reflex stimulation of vomiting and the side effects of erythromycin, no treatment, 1 ~ 2h after the symptoms disappear. Hemangioma of the penis size as much as possible on both sides of the needle from the penis, pay attention to the site of injection, level, medication dosage, to prevent the damage the dorsal penile blood vessels and nerves, and prevention of the occurrence of Peyronie's disease later. The current treatment of vascular tumors are more injectable drugs, such as the common Pingyangmycin,[link widoczny dla zalogowanych], but it may be hair loss, limb numbness, pneumonia and other serious complications of the kind of change, some patients Pingyangmycin allergies, and more expensive. Was 1 case of previous head type penis cavernous hemangioma in 98% ethanol injection, the penis head and local tissue necrosis, although the effect is acceptable but dose not easy to master. 1995 years ago, we applied local injection of tetracycline treatment on liver and kidney after there is damage due to tetracycline, affecting bone, tooth development, and gradually be eliminated. After 1995, use of erythromycin, clinical efficacy of certain low price, toxicity, dispensing simple and convenient treatment. Erythromycin is not only the role of tumor necrosis has to hardening, as well as anti-inflammatory effects, unmatched by other hardening agent, worthy of clinical application.
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