Forum pracy nad projektem wskrzeszenia The Forge

[yoylqnqvwb]

Isoniazid GITS


, Each 0.1g of isoniazid once a day to 03g,[link widoczny dla zalogowanych], still in the body to maintain a high plasma concentration. Although this regimen to maintain an effective blood concentration of relatively short when asked, but in fact has become a question we are now intermittent regimen used in the foundation. Isoniazid can be taught intermittent application of bacterial experiments confirmed soon. The experiment is certain TB Yin and drug exposure time, then moved to free TB drugs to wash away the drug medium. Mycobacterium tuberculosis growth observed lag phase. Results below. Various anti-TB drugs on the growth of TB latency _ Yin Kou column density growth delay of days Min Zhuo drug flail g/m1) mushrooms mushrooms 6 hours spermatogenesis spermatogenesis> hours vary Guo hydrazine l0B ~ 9 58 ~ lo contingent ADM , '8 ~ 1O_ rifampicin O. 22 ~ 32 ~ 3 topiramate spit bowl amine 5O5 ~ 40> 40 is different sulfur ring Dan amine '0 lO Divination alcohols lo004 ~ 8 have been provision of lo04 ~ 5 D amine volume bottles ADM lO6 19 from the experiment shows that the delayed growth of Mycobacterium tuberculosis with drugs and their concentration and time have different: in the delayed phase, the drug is not sensitive to TB. Medication or even completely ineffective at this time; before. Delay period. TB began to grow. At this point the drug-sensitive TB, drug effects are the best. Second, isoniazid GITS week application to achieve the purpose of intermittent drugs on M. tuberculosis growth from the above the delay of the experiment can also see, 1 / ~ g / ml concentration of isoniazid role of l2 hours, the growth of Mycobacterium tuberculosis almost no latency period. The role of the same concentration of isoniazid 24tj ~ when the delay in the growth of Mycobacterium tuberculosis is up to 6 to 9 days. This. We designed isoniazid once a week drug controlled release tablets. The first controlled-release tablets of isoniazid tablets with polymer material core, and then release the speed control outsourcing microporous films. 1.75g ​​oral dose of the patients after a blood concentration in vivo than lpg / ml,[link widoczny dla zalogowanych], and maintained more than 24 hours. Therefore, isoniazid can be achieved clinically controlled release tablets once a week, the purpose of medication. Third, the development of controlled release tablets of isoniazid has obvious social and economic benefits currently. Very serious epidemic of tuberculosis,[link widoczny dla zalogowanych], active tuberculosis present nearly 600 million, the number of people die from TB every year nearly 24 million. The number of deaths due to other infectious diseases than the total number of deaths more than doubled,[link widoczny dla zalogowanych], decades of medical practice and research that. In addition to the treatment of tuberculosis drug treatment programs should be a reasonable result of a failure of the most important reason. The patient does not adhere to the law of treatment. Therefore, patients and their families have repeatedly emphasized that adherence to law of all chemotherapy drugs importance. Whenever possible, each Jing drugs should be taken under the overall supervision. Beijing and other selection measures taken to obtain a great success. However, the experience across the country, so that supervision is still very difficult to completely several times a week. If you can reduce the number of drugs. Even once a week medication. Only the feasibility of the supervision. Since controlled-release tablets of isoniazid with streptomycin, rifapentine supporting applications. Long-acting drugs may be used as a standard intermittent therapy used widely. Head and lung specialist at home and abroad a wide range of attention. World Health Organization Collaborating Centre for TB chemotherapy (in Beijing) Director Professor Yan Biya hope this drug as a collaborating center of the development of drug research. World Health Organization, the UK's most authoritative experts in tuberculosis, Dr. FOX visited Shanghai Pulmonary Hospital, also expressed the first controlled release tablets of isoniazid great interest. I hope we developed this drug as soon as possible, in order to contribute to the cause of human health. To sum up. Controlled-release tablets as a drug isoniazid once a week intermittent therapy for tuberculosis asked specific drugs. Will greatly facilitate the drug. Reduce drug costs, well in favor Supervisory Management, to ensure treatment. This will improve the prevention and treatment of TB,[link widoczny dla zalogowanych], TB disease is clear the best way the role of short-tailed bird. International Federation of Tuberculosis and Lung Disease Treatment {social and economic benefits. Sampan foot: visit Wat embroidered, multi-drug treatment of rheumatism enough - Jin Nuofen Zhongshan Hospital, Shanghai Medical University, Lu Jiaming ● ● - _-_ - present. The treatment of rheumatism of four common drugs unreasonable friends: 1. Single-use non-steroidal anti-inflammatory drugs, although these drugs can inhibit prostate cable and reduce joint swelling and pain, but can not act on other media and to prevent bone and joint destruction; 2. Drugs by changing conditions such as gold preparations, penicillamine, cyclophosphamide. Gen {'3. s Tripterygium preparations amide and less. But these drugs can reduce the activity of the disease, slowing progression of the disease. Prevent or reduce damage to bones and joints; 3. Application of too much steroid hormone. They can only reduce joint swelling, pain, and not change the condition. And not easily disabled after use. Many patients with long-term use may cause systemic side effects,