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Stichopus variegates compound after balloon injury of rabbit arterial intima of blood lipids and


Significantly reduced intimal injury may be related to the synthesis of 6 weeks of bFGF and bFGF has passed the peak of the dual effects. TGF-G than with the promotion of VSMC migration,[link widoczny dla zalogowanych], proliferation, Durante and others also found that TGF-G can stimulate arginine transport and metabolism, promote collagen formation of the precursor of proline, thereby promoting collagen synthesis. Iindner ∞ confirmed that TGF-G is the arterial adventitia after balloon injury and fibrosis, an important regulator of vascular remodeling. In this study, observed by in situ hybridization of TGF-GmRNA expression in the blood vessels, compared with model group, Stichopus group and simvastatin group was significantly reduced TGF ~ G. Confirmed stichopus variegates compound on the expression of TGF-G significantly inhibited, in the course of its anti-AS. Animals from the sea echinoderms Stichopus door stichopus extracted mucopolysaccharide, mainly containing hexuronic acid,[link widoczny dla zalogowanych], fucose, galactose, hexosamine and other monosaccharides. Stichopus with Hawthorn,[link widoczny dla zalogowanych], yam and other traditional Chinese medicine fungus also has blood fat, anti-clotting effect. This experiment confirmed that stichopus variegates compound also can effectively adjust the lipids, and inhibit vascular remodeling after injury, reduce intimal hyperplasia and lumen stenosis, the role of growth factors and inhibition of synthesis and secretion. This study demonstrated stichopus variegates compound of hyperlipidemia,[link widoczny dla zalogowanych], coronary heart disease,[link widoczny dla zalogowanych], coronary artery restenosis after treatment of the clinical development of better value.