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Self Treatment of Stomach chronic atrophic gastritis 50 cases


:2005-12-20) Topiramate in childhood epilepsy in 45 cases von A Liu Xuemei this study in September 2002 to 2004 l2 month with topiramate monotherapy d, JL epilepsy in 45 cases, clinical results were satisfactory, are as follows. 1 Data and methods 1.1 General information: Department of our hospital 45 patients were children, aged l ~ l2 years old, an average of 3.5 years, 33 cases were male and 12 females, duration of 2 months to 4 years, an average of 7 months. The patients were in accordance with the d, JL domestic classification of epilepsy and the evaluation standard diagnostic criteria, the treatment type, seizure frequency and treatment efficacy evaluation. 29 cases in which focal,[link widoczny dla zalogowanych], comprehensive ll cases, WestS5 cases. All patients were given topiramate monotherapy, in which poor due to other drug treatment and gradually switching to topiramate monotherapy l9 cases, for the first time given topiramate monotherapy in 26 cases. 1.2 Treatment Methods: Xian-Janssen Pharmaceutical Co., Ltd. production of topiramate (brand name: Topamax), the initial dose of 0.5 ~ lmg · kg-I, d ~, day 1, every increment 1, increment is still 0.5 ~ lmg · k ·, the largest target for the 4mg · kg-t · d ~, control 2 to 3 years after onset of treatment plan and then reduction. l-3 laboratory examination: Before treatment, patients were checked for each EEG,[link widoczny dla zalogowanych], brain CT, a full set of biochemical, blood, urine analysis, hepatitis B and other five were classified to find the cause so treatment l, 3,6 and 12 months respectively, liver function, blood routine, urine analysis, no significant effects. 1.4 therapeutic efficacy: a week after the start of treatment were followed up for 1. After 1 month follow-up markedly, to evaluate the reduction under attack: ① markedly: complete control of seizures; ② Effective: seizures decreased 50% ~ 99%; ③ invalid: less than 50% seizure reduction. 1.5 Adverse reactions: loss of appetite, anorexia in 5 cases (11.1%), weight loss in 4 cases (8.8%), no sweat, less sweat, fever in 2 cases (6), lethargy (2 cases, 0.40 / 0), irritability, restlessness,[link widoczny dla zalogowanych], l cases (0.2%), headache, dizziness l cases (0.2%), difficulty finding the word l cases (0.2%), in a daze, unresponsive l (n = 0.2%), paresthesia, l cases (0.2%), memory loss, 2 cases (0.4%), learning is not good, lack of concentration l cases (0.2%). 2 results of treatment of children with epilepsy, topiramate effect: see Table l. Author: 264002 Yantai, Shandong Province Fenghuangtai Hospital Pharmacy (von A); Yantai, Shandong Building Juan top Department of Pediatrics (Liu Xuemei) wrapped in a topiramate treatment of children with epilepsy efficacy of 45 patients were involved in the whole treatment,[link widoczny dla zalogowanych], follow-up, 9 patients in the treatment of 7 months after the lost, can be seen from Table l, topiramate monotherapy for epilepsy treatment, complete control rate was 57.7%, adverse reactions, mostly in the initial stage of treatment, no serious adverse reactions. 3 to discuss the structure of Topiramate belongs to a new antiepileptic drug, has found there are three kinds of mechanisms of antiepileptic effect: ① topiramate y an increase in cerebellar granule cells aminobutyric acid (GABA-A)-mediated chloride ion influx, which is not the role of benzodiazepine antagonists blocked, and phenobarbital regulating GABA-A receptor and topiramate did not increase the ion channels open. ② topiramate voltage-dependent sodium ion channel regulation. ③ topiramate voltage-dependent and receptor-dependent regulation of calcium ion channel. ④ with voltage clamp technique found topiramate to block kainic acid-mediated currents. Reduce the excitability of neurons, suggesting that topiramate can antagonize glutamate receptors by kainic acid, AMPA subtype. Topiramate has been widely used in various types of domestic and international epilepsy with partial seizures and generalized seizures in the treatment and for Lennox-Gastaut syndrome and refractory partial seizures are also effective. Complete control rate of 57.7%, single drug therapy can also be combined with other antiepileptic drug treatment, dosage (target dose) 4mg · k · dt, attention to human differences, adverse reactions, mostly in the initial stage of treatment. In this study, a variety of adverse reactions in patients and found that the majority of topiramate adverse events occurred in 1 month after treatment, and weight loss tends to occur in the administration of the first 3 months. Many studies suggest that topiramate adverse reactions related to the central nervous system. Most dose adjustment at the beginning of the 8 weeks there. Manifested as dizziness, psychomotor retardation, lethargy, difficulty concentrating, fatigue, ataxia, speech disorders and sensory dysfunction, and more continue to disappear after treatment observed,[link widoczny dla zalogowanych], seldom discontinued due to adverse events.