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 Posted: Sat 17:36, 26 Mar 2011 Post subject: puma shoes N-(5 - methoxy -3 - indole-ethyl) -4 a |
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N-(5 - methoxy -3 - indole-ethyl) -4 a substituted phenylpiperazine -1 - α1-receptor antagonist acetamide Synthesis and biological activity
iflPC, K ~ ooorV, AnandN. G8 flail nsmthe ∞ naln ~ rvou $ system. Ⅶ. StudiesinI-py. dyt-4-= hett ~ tedpem. Anewclassofanticonvulsants [J]. JMed hesitating, l, 1967,[link widoczny dla zalogowanych], plus (5): 812 -818. [8jJudithAK, DavidKY. Synthesisq. Rntitaljve God m song Ⅲ · flail vityrelationshipsof8 ∞ ∞ antibacterial3 a woman Diao lIiISV Ⅳ - (4.substitutedpheny1) pipeminoaceth ~ es [J].-R Shí O, tm, 1978,2 l (12) :1301-1307. [9jCookDJ, Bow ~ llRE. Btomiaafiansllldi ~ of carp bBlm2 · pyridonesand2-quinolo ~ [1]. JOrgO, tm,[link widoczny dla zalogowanych], 1961, (t2) :4949-4955. [10] KolkamiGM, KulkamiMV . Synthesisandanti-. Cape aetlvityofSortienewtriheterocycle a bleed at the nose n_nH _ crucible ∞ Les 【 】 ]. j} Ra ~ naine from the aIm women, 1990.35 (4): 549 -554. SynthesisandBiologicalActivitiesofN one (5 a Methoxy a 1H-indole - 3 a ethy1) -4 aaaa aceticAmideDerivativesasOc1 SubtitutedPhenyIpiperazine a AdrenOCeptOrAntagonistsWUBin,[link widoczny dla zalogowanych], XIALin, JIANGZhen-ZhouDepartmentofMedicinalChemitry,[link widoczny dla zalogowanych], XinzhongNewDReseawhandDevelopmentCenter, Chinam ∞ University, Nanjing210009, China 【 ABScT 】 AIM: Tostudythesynthesisandanti-a1-adrenoceptoractivityof5 a me Ⅱ y 】 phenylpiperazinecompounds. M stare HOD: Cyclization, substitutionandamidationreactionswereusedinthesynthesis0fthetitlecompounds. 111einhibitionactivityofthetargetcompoundsweretested. RESULT: Fourteennewcompoundsweresynthesized. StructureofthetitlecompoundsweredeterminedbyIR, HNMRandESI-MS. CompoundsWBI a 2, WB workers a 3,[link widoczny dla zalogowanych], WBI-4, WBI an 8, WBI a 9andWBI a 14showedinhibitionactivity. CONCLUSlON: 1potency (pA2) ofthetitlecompoundswaslowerthanthoseofcontrolPrazosin. 【 KEYWIORDS 】 Phenylpiperazine; 5 a Methoxytryptamine; ctI-Adrenoceptorantagonists; Synthesis; Activity 】 【 Foundat ~ Item ThisprojectwassupportedbytheNational More articles related to topics：
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