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p90x calendar MAPK信号转&#

 
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Cholerny Spammer



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PostPosted: Wed 14:33, 02 Mar 2011    Post subject: p90x calendar MAPK信号转&#

MAPK信号转导途径在Mtb-Ag激活的γδT细胞杀伤肿瘤细胞中的作用
促进细胞中的颗粒外排,而对Fas/FasL途径的影响较小。另外,PD98059虽可抑制"yST细胞杀伤K562细胞,[link widoczny dla zalogowanych],但不能完全抑制",/ST细胞的细胞毒活性,提示",[link widoczny dla zalogowanych],/ST细胞细胞毒活性的启动可能还涉及其他信号途径。CD69是淋巴细胞活化后较早表达的表面分子,被认为是淋巴细胞早期活化标志。因此,[link widoczny dla zalogowanych],我们检测了",[link widoczny dla zalogowanych],/ST细胞与肿瘤细胞作用后,以及被PD98059和SB203580分别阻断后CD69的表达。结果表明,PD98059能明显抑制CD69的表达,而SB203580无此作用,提示ErkMAPK途径参与了肿瘤细胞对细胞的活化。最近,[link widoczny dla zalogowanych],Zingonl等报道,CD69的交联可启动信号转导的级联反应导致Erk的活化。但本研究则表明,Erk的活化可引起",/ST细胞上CD69的表达,因为Erk的抑制剂PD98059能抑制8T细胞表达CD69。当然,也不能排除CD69表达后再促进Erk活化的可能性。
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