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NMDA and GABA receptor antagonists on nerve cells in Parkinson's mouse model of


Neurotransmitters and ischemic brain injury, Neurology MEDICAL SCIENCES SECTION , 1993.20 (1): 16 [4] WachtelH. KunowM, LoschmannPA, NBQX (6 a nitro-sulfamoyl-benzo-quinoxaline-dione) andCPP (3 of a carboxy-pipereain-propyl-phosphonieacid) potentiatedopanfineagonistinducedrotationsinsubstantlanigralesionedrats. NeurosciLett, 1992,142 (2): 179 [5] WeihmullerFB, UlasJ. NguyenL, CotmanCW, MarshallJF. Elevat. edNMDAreceptorsinparkinsonianstriatum. Neuroreport, 1992,3 (11): 977 ( Received Et on 2006-04-2 EffectofKetamineandBicucullinonDopamineNerveCellinMiceModelofParkinson'SDiseaseWANGChuangong, WANGXM, 0.1Ruxia (Departmentofpharmacology, Jiningmedicalcollege, Shandongjining) AbstractObjectiveTostudytheeffectofKetamineandBicucullinonthedopaminenerveeellofthemicemodelwithParkinson'Sdisease (PD). MethodsTheanimalmodelofPDwaspreparedbyinjectedwithMPTPinC57BLmice, theninjectedwithKetamineandBicucullinrespectively. Thecha ~ geofdopaminecellwasobservedbymicroscope. ResultsThenervecellsweredestroyedinBicucullingroup, However, thedestroywasweakenedandinflammatorycellsobviouslyreducedinKetaminegroup, Thedenaturalizatedceilssignificantlyin-creasedinBicucullin + MPTPgroup, comparedwithMPTPandKetamine + MPTPgroup,[link widoczny dla zalogowanych], (respectively, P <005). ThedenaturalizatedcellssignificantlydecreasedinKetamine + MPTPgroup, comparedwithMPFPgroup (P <0.05). ConclusionBicucullinbroughtaboutthedenaturalizationofnervecell, itmayparticipateinthepathogenesisofPD. ~ owever, Ketamineweakenthedestroyandmayrepairthenervecel1. Therefore, Ketami ~-lemayserveasanewtherapyforPD. KeywordsParkinson'sdisease; Bicucullin; Ketamine; Dopanlinenervecell; pathology