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Cholerny Spammer
Joined: 17 Nov 2010
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Location: England
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 Posted: Thu 21:35, 17 Mar 2011 Post subject: Mulberry handbags Interleukin- 1 on intervertebral |
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Interleukin- 1 on intervertebral disc cartilage -specific gene regulation of Sox9 mRNA
Expression was gradually decreasing trend ; II collagen gene mRNA expression with time has also been similar results. This shows that in the human intervertebral disc cells in the IL-1 can also be time-dependent manner by the negative regulation of chondrocyte specific genes Sox9 and type Ⅱ collagen gene expression. These results suggest that we ,[link widoczny dla zalogowanych], in the process of disc degeneration , IL. 1 significantly inhibited the biological effects of Sox9 gene , and further affect the type Ⅱ collagen gene expression and product of the synthesis , so that the disc cells of extracellular survival of physical damage to the environment , gradually increase the incidence of disc degeneration , Development, and to have taken place in the intervertebral disc degeneration is difficult to achieve self-repair . For IL-1 can affect the mechanism of disc degeneration need more in-depth study of molecular mechanisms ; in the IL-1 inhibited the process of Sox9 gene function , in addition to NF. KB pathway other than whether there are other regulatory mechanisms , also need to be confirmed ; In addition,[link widoczny dla zalogowanych], degeneration of the intervertebral disc tissue within the Sox9 gene is lower than the normal disc ,[link widoczny dla zalogowanych], and its gene expression is reduced; in the process of disc degeneration , the existence of Sox9 gene mutation ? to the degenerated intervertebral disc cells transfected with Sox9 gene ,[link widoczny dla zalogowanych], degeneration of the intervertebral disc asked whether there would be reversal of the performance ? these issues are to be in the next series of studies related to depth.
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