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 Posted: Sun 6:38, 30 Jan 2011 Post subject: moncler outlet Hemoglobin and altitude hypoxia ada |
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Hemoglobin and adapt to high altitude hypoxia
Adapt to the crowd while the high altitude hypoxia and the expression of Hb HIF. A relationship is not sure. Moore and other measured 146 Tibetan native who myoglobin gene in the second exon (Exon2), found that myoglobin 72A allele frequency higher than the plains of the control group, but the Tibetans did not show polymorphism Exon2 difference, and between Hb and no obvious correlation. The structure of human hemoglobin has been found that many human globin a and J3-chain variants, which greatly improved the oxygen binding capacity (known as the high oxygen affinity variant.) Directed mutagenesis using the point mutation make Hb gene expression produced a chain of 119 globin proline was replaced by alanine, J3 chain of serine 55 was replaced by leucine mutation, the affinity of oxygen greatly increased. But so far, been found associated with high altitude native population of high oxygen affinity Hb variants. 5 Conclusion This paper described the plateau plateau native animals and native people function and structure of lib Note: organisms living on the plateau the more ancient times, the more comprehensive hypoxia adaptation, the less compensation in a simple environment to increase the Hb hypoxia,[link widoczny dla zalogowanych], but in lib improve the structure and function to enhance the affinity for oxygen. Category 3 to adapt to high altitude hypoxia on the number of people of different Hb, but also prompts people to adapt to the altitude hypoxia on the expression of Hb, it is possible to adapt to different mechanisms. Currently,[link widoczny dla zalogowanych], the Plateau Native population genetic mechanism of adaptation to high altitude hypoxia has not been elucidated,[link widoczny dla zalogowanych], molecular biology and bioinformatics techniques and methods,[link widoczny dla zalogowanych], research and looking for people to adapt to high altitude hypoxia of high altitude hypoxic adaptation Hb and other genes, there may be reveal the mechanism of high altitude hypoxic adaptation provide important clues.
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