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PostPosted: Fri 3:21, 25 Feb 2011    Post subject: moncler outlet 中药糖&#227

中药糖复康降糖作用的药效学研究
g剂量组血糖分别为(265±149)mg/at和(250土107)rag/d1.与高血糖对照组相比,对血糖升高的抑制率分别为38.B和42.2,有较强的降高血糖作用(P<0.O1),金芪降糖片天律中医l998年lO月第15卷第5期15g/kg组的抑制率为2g(P<0.05),见表4.表4糖复康对四氧嘧啶致高血糖小鼠血糖的影响分组血糖值药物剂量(g/kg)动物(其)士空白对照1O86士l8高血糖对照1O433土107&降糖灵lOOrag/kglO304土159盎芪降糖片l5lO309士1477.5l0265士1糖复靡1510250士107洼:与空白对照相比.&,<10;与高血糖对照相比.*P<0.05**P<o.o1.由上述可见,在同一剂量情况下,糖复康的降高血糖作用最强,其次为降塘灵和金芪降糖片。5对原发糖尿病鼠NOD鼠血糖的影响5.1动物{NOD鼠25只.体重17~l9g,雌雄兼用。饲料由北京医科院动物繁育场提供,为专用消毒饲料。饮用水为消毒的1酸化水,[link widoczny dla zalogowanych],饲养环境为隔离消毒清洁级别的实验室。5.2实验方法:NOD鼠经1周观察后,禁食20hr取血测血糖,血塘平均为(73.74-9.3)mgl~.分为空白对照组6只、金芪降塘片lsg,kg组6只、糖复康7.Sg/kg组6只、1,$ttkg组7只,组间血培平均相差不超过5mg/d1.空白对照组灌胃给水,lml/]H.其余3组按规定剂量灌胃相应的药物,连续2周,末次给药后30hr(禁食20hr),取血测血塘,[link widoczny dla zalogowanych],结果用l检验分析。5.3实验结果:空白对照组血塘(105.74-11.7)mg/al;糖复康7.2255g/kg组、15g/kg组血糖分别为(91.3士41.7)mg/dl和(86.I士18.4)mg/dl,表明有抑制血塘升高的作用.尤其15g/kg组差异明显(P<0.05),[link widoczny dla zalogowanych],并且塘复康降塘作用优于金芪降塘片组,见表5.表5糖复康对原发性糖屎病鼠NOD鼠血糖的影响分组血糖值药物剂量(glkg)动物(其)士空白对照6105.7土l1.7盘芪降糖片l5691.4土l1.7注:与空白对照相比*尸<O.05.6讨论糖复康对正常大鼠的血糖无影响}对氨基葡萄糖和四氧嘧睫所致的动物高血糖有显著的降血塘作用;尤其对原发性塘尿病鼠NOD鼠有抑制血糖升高的作用。进一非化学性高血塘动物模型更接近于临床中非胰岛素依艘型糖尿病的病生理基础,因此其降塘作用更有意义,[link widoczny dla zalogowanych]。同时,实验还显示在同一剂量情况下.糖复康的降高血糖作用优于降糖灵和金芪降塘片,是一种很好的应用于I型糖尿病的中药制剂。消渴证患者阳气虚.阴津不足.病标在肺,胃,府本在肾,故其治在肾.根据善补阴者必于阳中求阴、善补阳者必于阴中求阳的指导思想,糖复康用仙灵脾补肾扶阳,黄芪盏气升律,生地、女贞子滋阴补肾,使阳得阴助而生化无穷,阴得阳生而泉源不蝎。葛根生津止渴、升举清阳,丹参活血化赛。全方配台有开肾气以溉二焦的作用,[link widoczny dla zalogowanych]。
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