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Inhaled corticosteroids efficacy of the treatment of acute bronchitis


, AstraZeneca),[link widoczny dla zalogowanych], 200, 2 times a day, 15d is a course of treatment. Control group, 24 cases are not given hormone treatment to cough,[link widoczny dla zalogowanych], phlegm-based, with purulent sputum were treated with vitamin therapy. Observed indicators to clinical remission rate based. Also include the duration of cough, purulent sputum of change. Some patients,[link widoczny dla zalogowanych], fiberoptic bronchoscopy and chest radiograph review. 1.3 Statistical analysis: All data processing package SPSS10.0 medical statistics, calculations for that line of data normality test. 2 Results inhaled corticosteroid group of 25 patients, mean cough 12.5d, relief in 24 patients (96%); the control group 24 cases, the average cough 19.5d,[link widoczny dla zalogowanych], remission in 16 patients (66.7%). The mean number of days coughing, alleviate the number of cases,[link widoczny dla zalogowanych], compared with remission rates, both P <0.05. 3 discussions conductive airway inflammation is mucosal inflammation-based diseases. Such as rhinitis, sinusitis, laryngitis, bronchitis, COPD, bronchiectasis psychosis [3]. Conductive airway inflammation is due to pathogenic microorganisms and environmental pollution and other physical and chemical factors, especially the impact of smoking, resulting in conductive airway epithelial injury. Epithelial injury can make the loss of epithelial integrity, leading to antigen and harmful substances into the airway mucosa. Sensory nerve endings exposed, neurokinin, P-reactive substances increased, resulting in airway smooth muscle spasm; while epithelial cells to produce cytokines and adhesion molecules, the inflammatory cells (such as neutrophils, macrophages, etc.) gathered in airway , migration, activation, which further release of inflammatory mediators such as tumor necrosis factor 『(TNr) a, interleukin (IL) A lB, IL elastase, an 8 and a variety of other】 further increase epithelial damage, eventually leading to glandular secretion disorders, increased vascular permeability, increased airway smooth muscle tension and increased airway responsiveness. Pathogenic microorganisms is actually from a (or other biological, physical and chemical factors) infection or irritation of inflammation, is turning into a host organism cell-mediated inflammatory process. Inflammatory cells release inflammatory factors further exacerbate the process of airway inflammation, which is conductive airway vicious cycle of chronic inflammation, and anti-infection therapy alone cough treatment is not enough to break the vicious circle of f. The study found that inhaled corticosteroids to patients with bronchitis symptoms was significantly shorter time. Improve the response rate, indicating that a significant effect of bronchitis, which may be due to a strong inhibition of glucocorticoid and inflammatory factors in inflammatory cells, blocking the airway inflammatory process, thus breaking the vicious cycle of airway inflammation. The clinical observation only from the perspective of research, also need to assess airway inflammatory cells and changes in inflammatory factors, and study of inhaled corticosteroids for other types of conduction disorders role of bronchitis, due to inhaled corticosteroids for asthma and chronic obstructive lung disease has been recognized by the majority of medical workers. Accepted by most patients, which has a systemic side effects, the role of good local features, such as conductivity can be used in airway inflammation, these patients will bring many benefits.