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Acupuncture treatment of substance addiction biochemical mechanism hypothesis


A enkephalin opioid peptides activate a - boat enkephalin secretion in tegmental area, and the inhibitory receptor interaction, control aminobutyric acid (GABA) release. Enkephalin and (or) other opioid peptides then fine-tune the entire system. - GABA is to control the primary role of dopamine in the tegmental area of Taiwan into. Can inhibit the activity of a GABA Taiwan into dopamine. - By 7-GABA inhibitory influence of dopamine on the two structures: direct role in the nucleus accumbens and the amygdala, the indirect effects on the hippocampus area of the set of clusters of cells in these two regions which are the target messenger as a reward . In equilibrium, the system adjust so that all parts are in steady state, however, when neurological and biochemical dysfunction or failure of receptor binding, the steady state is broken, it will lead to emotional and behavioral changes. Mackler and Eberwine that this imbalance can be derived from genetic factors or long-term use of addictive substances and the formation of negative feedback. 3 cascade theory of acupuncture and the reward that the 5-HT Blum launched reward cascade system. ,5-HT there is evidence that acupuncture,[link widoczny dla zalogowanych], especially in the high-frequency electroacupuncture (50 ~ 2000Hz) play an important role. Most of this evidence comes from studies of acupuncture analgesia. SeanScott so that the needle is in the hypothalamus by increasing the content of 5 HT to a direct impact on reward cascade effect. Studies have shown that acupuncture activates the front side of the beam to be down 5-HT pathway, when carried out in the appropriate acupuncture points, the spinal cord dorsal horn receive nerve impulses, these impulses all the previous lateral conduction fibers, a considerable number of fibers, particularly in the spinal cord mesh beam and beam projected onto the brain directly affects the brain of a descending 5 HT energy system. There hypothalamus and midbrain neural pathways of mutual feedback and adjustment. So, by stimulating the descending 5 HT can be a pathway within a cascading effect in the reward of 20 * International Journal of Chinese Medicine Volume 20, 1998 No. 4 of the 5-HT directly affected, resulting in the nucleus accumbens and amygdala the increase of dopamine and the production of a subjective feeling of euphoria. Most drug addiction treatment clinics are using the ear of substance abusers, particularly worth mentioning is the ear Point right in the cutaneous branch of the vagus nerve,[link widoczny dla zalogowanych], the reason to believe that, through the acupuncture points to stimulate the vagus nerve to restore the network structure of arsenic dynamic neuronal activity, stimulation of the hypothalamus, launched reward cascade system. 4 Conclusion The increase in the hypothalamus of 5 -HT ancient volume, acupuncture can reward cascade of complex function returned to normal, so the addicts by acupuncture treatment not only alleviate the withdrawal symptoms, but also reduced demand for goods as intended. When the cascading effect reward The function was normal, the patient after the treatment there will be a sense of peace and euphoria. Therefore, acupuncture can not only treat withdrawal symptoms, and addiction Pin can be used as a means to prevent reuse reward cascade system damage,[link widoczny dla zalogowanych], in addition to causing addiction from the outside I may present other mental disorders. Acupuncture can be a brain 5-HT machine {} I can alleviate the symptoms of mental disorders more than root, which for depression and mood disorders,[link widoczny dla zalogowanych], especially seems to effect Jia, however,[link widoczny dla zalogowanych], reward cascade system in the body's normal function is still unclear reward cascade hypothesis for our understanding of physical mechanisms of addiction and acupuncture provides a variety of possibilities for its further research is very necessary. 5
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