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MBT Cipő Tamoxifen combined with mifepristone for

 
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Cholerny Spammer



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PostPosted: Thu 5:18, 17 Mar 2011    Post subject: MBT Cipő Tamoxifen combined with mifepristone for
Tamoxifen combined with mifepristone for early pregnancy chorionic VEGF, TGF-β1 expression


leedingaftermedicalabortion. Methods: Fiftywomenwithin49dofintrauterinegestationwererandomlydividedintotwogroups. Tamoxifen120mgcombinedwithmifepristone150mgwasadministeredorallytothegroupA,[link widoczny dla zalogowanych], followedbymisoprostol600Ixgorally. Placebocombinedwithmifepristone150mgwasadministeredorallytothegroupB, followedbymisoprostol600Ixgorally. Twentyonewomenwhoselectedvacuumaspirationwereascontrolgroup (groupC). ChorionicvilliwerecollectedandexpressionofVEGFandTGF-131weredetectedbyhimmnohistochemicalmethods. Integratedopticaldensity (IOD) ofVEGFandTGF. 131wasdetectedbyusingspecialimageanalysissoftware. Results: VEGFproteinwasexpressedinallsyncytiotro-phoblastcells,[link widoczny dla zalogowanych], eytotrophoblastcellsandvascularendothelialceUs,[link widoczny dla zalogowanych], andwasexpressedininterstitialcellsmostly. TGF. D1proteinwasexpressedmostlyinsyncytiothrophoblastcellsandcytotrophoblastcells, andlialeininterstitialcellsandvascularendothelialcells. IODofVEGFandTGF · 131expressionofgroupC,[link widoczny dla zalogowanych], groupB,[link widoczny dla zalogowanych], groupAreducedonebyone. TIledifferencebetweenanytwogroupwassignificantstatisticallyfP <O. 05) (IODofVEGF: 53954.56 ± 15946.22,42436.744-12979.98 & 33452.49 ± 10666.87; IODofTGF.13l: 59915.28 ± 19219.37,40880.01 ± 18022.13 & 29823.02 ± 12357.60). Conclusion: ItisspeculatedthatmifepristoneresistsearlypregnancybecauseitsuppressestheexpressionofVEGFandTGF · DIonchorionicvilli. Tamoxifencouldstrengthenthiseffectofmifepristone, soitcouldshortenthedurationofvaginalbleedingaftermedicalabortion. Keywords: tamoxifen; mifepristone; chorionicvilli; VEGF; TGF · BI; Irophoblast - 203 -
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