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Cholerny Spammer
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 Posted: Sat 2:33, 19 Mar 2011 Post subject: MBT Cipő Arsenic trioxide treatment of promyelocyt |
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Arsenic trioxide treatment of promyelocytic leukemia by multiple joint effusion in 1 case
iratorypathogenLJ on FrontBiosci ,2002.7:66-76. [2] Collaborative Group of China pediatric asthma. Conventional prevention and treatment of asthma in children (Trial) population]. Pediatrics. 1998.36 (12) :747-750. [3SuttithawHW, wangro ¨ DngsarbP. NaigowitP, etal, Chlamydophila (Chlamydia) pneumoniaeasacauseofcommunity-acquiredpneumoniainThailand [J]. JMedAssocTha1.200l, 84 (3): 43O a 437. [4: Nian Ping. Wang Hui, Dong Ping, et al,[link widoczny dla zalogowanych], pneumonia, bronchitis and acute upper respiratory tract infection of Chlamydia pneumoniae infection [J]. Journal of Internal Medicine, l995, 34 (6) :388-390. [55BlackPN, BlasiF. JenkinsCR,[link widoczny dla zalogowanych], eta1. TrialofroxithromycininsubjectswithasthmaandserologicalevidenceofinfectionwithChlamydiapneumoniae [J]. AmJRespirCritCareMed, 2001.164 (4) :536-541. △ HOSPITAL, Chaoyang District, Changchun City, arsenic trioxide treatment of promyelocytic leukemia by multiple joint effusion in 1 case the First Hospital of Jilin University, Hematology and Oncology Huang Yun, Yang Yan 1 clinical data of patients, male, 13 years old,[link widoczny dla zalogowanych], dizziness , weakness, pale 6 months, at 1O 8 March 2000 into the hospital. Examination: appearance of severe anemia, chest tenderness positive. Blood: WBC22.7 × 10 · L_. , RBC]. 90xl0 · I, hemoglobin 59g · L-. , Platelet 38.0 × 10 · L_. , Bone marrow biopsy: nuclear proliferation is extremely active, promyelocytic 0.85. Visible in small cytoplasmic granules addicted to Azure,[link widoczny dla zalogowanych], and see Auer bodies, other systems inhibited. Karyotype 46, XY,[link widoczny dla zalogowanych], t (15,17). RT-PCR showed PML-RARc ~ mRNAS type (+). Diagnosed with acute promyelocytic leukemia. Arsenic trioxide (containing arsenic trioxide 1g · L) daily 7mL intravenously. Arsenic treatment of 9 days, the patient began to both lower extremities and buttock pain, fever (38.2 ~ 395'C), no abnormal chest radiograph, blood culture, bone marrow cultures were negative. Double hip high skin temperature, local activity limitation, the right 4 words test positive, two hip radiographs show joint space is increased. Double knee swelling, tenderness positive, floating patella test positive, double positive for ankle swelling tenderness. Has used a variety of broad-spectrum antibiotics (Ling Lan Xin, imipenem) and the joint use of antifungal drugs (large F Kang, fluconazole). Fever does not get better. Line hip joint cavity puncture, joint effusion culture was negative; routine and biochemical examination: WBC21 × 10 · L_. , RBC25 × l0 increased due to bone pain, the treatment of pine with a strong increase oral 30mg daily, while continuing application of arsenic. but tapered to 4mL · d_., to 46d when the symptoms of leukemia in patients with complete remission and discharged. 2 is the second discussion of arsenic trioxide After retinoic acid treatment of acute promyelocytic leukemia cells is another important finding epilepsy, its high rate of disease remission. relatively few side effects. literatures have nausea, vomiting, fever, bone and joint pain, breathing difficulties, white rose Vice ashamed of higher use. but never had significant joint effusion. arsenical treatment of joint effusion occurred during the same time accompanied by fever, leukocytosis. misdiagnosed as infection, septic arthritis, this time to pay attention many times to do the blood and various secretions training. exclude the possibility of infection and sepsis, so conducive to intra-articular biopsy diagnosis. If arsenic caused by joint effusion may tend to increase with hormone, while paying attention to arsenic reduction. △ undergraduate student (Changchun l30021)
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