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Yangzhong County,[link widoczny dla zalogowanych], a high incidence of gastrointestinal cancer and the family's genealogical survey of cytogenetic testing


As the Ministry of patients and their family j ram member to cover peripheral blood lymphocytes (a) of the 126 side of the road on the insults of cancer patients, found tied to measurement and analysis and micro edges, and the establishment of the control larvae. Appear in the same generation or two cancer patients for 2 or 3 generations (a) subjects were suffering from digestive tract cancer are 52,[link widoczny dla zalogowanych], accounting for survey 1. Pain patient group: family history of cancer have a high cancer is 41.27% Zhu, see the genealogical chart. Patients with 14 sides,[link widoczny dla zalogowanych], including the 7 cases of gastric cancer and esophageal cancer. Male, 2. The group of high prevalence of cancer family shown below. ● beans are 1 Ⅳ map. Consumer creek channel on the high-Lei Lu strong love of family reform plans to marry dumb symbols that spring smell Table l52 households with high cancer compared the situation of family members of cancer 3. Of familial clustering of upper digestive tract cancer with the same phenomenon of a statistical life history, and the results shown in Table 2. The relationship between genetic factors, according to whether the passage of blood relationship and the presence of a total of 2 blood ties, and relations between lifestyle factors and cancer 4. SCE values ​​of each group is shown in table 3 Table 8 prepared by comparing the value of maggots in the SCE Note t compared with the control group of cancer t members of the group and the control group; high Shatter domain member of the family group t5. The micronucleus test results of the comparison group in Table 4 Table 4 Comparison of lymphocyte micronucleus test spin Lian Note: the cancer group compared with the lag 'j members of the group and the control group compared with high cancer family members of cancer families and family groups Dian bite of high cancer were 000, l / PPP group http home set high cancer! border A pair of 0O0PPP · 286 · discuss one family gathering on the upper digestive tract cancer,[link widoczny dla zalogowanych], and genetic factors in the understanding of the phenomenon: some of the familial cancer clustering phenomenon has been well known. In this paper, from 1988 to 1989, Department of Pathology confirmed upper gastrointestinal cancer patients randomized to genealogical survey: 52 in three successive generations of cancer in 6 households (11.54), 42 consecutive cancer second-generation households (80 .77%). Maternal cancer rate (34.61) than the parent (30.77%), a statistically significant difference (P> 0.05). Such a manner consistent with vertical transmission of single-gene Mendelian autosomal dominant characteristics. Table 2 also initially showed that 52 had a family history of high cancer families, the authors investigated a total of l335 people, in a common life cycle of the crowd, with or without blood ties between the rate of cancer patients were significantly different (P <0. O1). Of the findings, upper gastrointestinal cancer Yangzhong County family agglomeration evident, and shows in which genetic factors play an important role. Also confirmed that environmental factors also induced upper gastrointestinal cancer can not be ignored. But cancer is a complex tangled Gang, to be further research and discussion. Two pairs of upper digestive tract cancer, cancer, family members of high SCE measured diameter orange Rang meaningful rub: With the development of cytogenetics, SCE and micronucleus test more for the current Journal of Clinical Oncology Pat. SCE analysis is found in chromosome damage and repair of the highly sensitive method, and micronucleus test is a new system for the determination of cell genetics. Closely related with the chromosome analysis. Funeral 3,4 The results showed that the high cancer of upper digestive tract cancer patients and their family members in the SCE values ​​and higher micronucleus rates. This shows the high Yangzhong County, there are family members of cancer of upper digestive tract cancer or cancer risk among vulnerable populations, and such groups}} {is mourning family members out of high cancer there is some genetic factor, which ignored the child in received varying degrees of long-term external environment factors or cancer-promoting factors induced the role of lame to make it a mutation, it is easy to produce than others of upper digestive tract cancer. This monopoly of wisdom, according to surgery group results, combined with the relevant literature, the authors believe SCE and micronucleus test in the diagnosis of skin disease on the digestive tract is indeed a valuable reference. Particularly high incidence of upper digestive tract cancer, cancer prevention guide has some training in this small group of family history of 126 cases of upper digestive tract cancer survey, Yangzhong County, Jiangsu Province, the incidence of upper gastrointestinal cancer have obvious family genealogical survey of 52 sub-family of Gardenia that agglomeration of the disease and genetic factors and environmental factors by SCE and micronucleus test results showed that family members of high cancer may easily confused with upper gastrointestinal cancer and cancer risk among people. Preliminary results show that this group Yangzhong County, the incidence of upper digestive tract cancer characteristics, prevention and control work on the future provide important clues. . Reference quiet 1. Wu Man, et al. Linxian People's Hospital even cancer, cardiac distribution of ABO blood of cricket. Oncology 198118 (1) l162. Yu-love, and so on. Genetic etiology of esophageal I Don Genetics 1979j6 ( l stare 73. Zhang Zhilan, et al. Yangzhong County cancer death investigation. 1988 Chinese Journal of swollen places 10 (1) - pumping 24. CartSA. S ~ sterchromatldexchzage. Geaetics1979, (92) l83
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