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HIV侵入抑制剂的研究进展
Chun．Lei,[link widoczny dla zalogowanych]。，RUANLi．Jun2，CHENDai．Jie2．3,[link widoczny dla zalogowanych]，ZHUBao．Quan《1．XinchangPharmaceuticalFactory,[link widoczny dla zalogowanych],ZhejiangMedicineCo．Ltd．．Xinchang312500；2．ShanghaiInstituteofPharmaceuticalIndustry，Shanghai200040,[link widoczny dla zalogowanych]；3．ShanghaiHealthCreationCenterforBiopharmaceuticals尺＆D，Shanghai201203)ABSTRACT：TheprogressofvariousHIVentryinhibitorsandtheirmechanismarereviewed．KeyWords：AIDS；HIVentryinhibitors；review·····囊··································(上接第681页)PreparationofSilymarinSelf-emulsifyingMicroemulsionXIAOYan-Yu,[link widoczny dla zalogowanych]，SONGYun-Mei，CHENZhi-Peng，PINGQi-Neng(Dept．ofPharmaceutics，ChinaPharmaceuticalUniversity,Nanjing210009)ABSTRACT：Thesilymarinself-emulsifyingmicroemulsionwasprepared．TheformulationofthepreparationsuchasOil．surfactantandcosolventwasselectedbydeterminingthesolubilityofsilymarinanddrawingpseudo—ternaryphasediagrams，usingparticlesize，emulsificationtimeandcolorofemulsionastheevaluationindexes．Theresultsshowedthatthesatisfactoryselfmicroemulsifyingeffectwasobtainedwhentheformulationcontaing5％silymarinusingMCT(mainlyglycerinoctanoateanddecanoate)asoil，CremophorRH40assurfactantand1，2一propyleneglycolascosolventintheproportionof0．5：5：3．6：0．9．Theaveragediameterofthepreparationwas68．6nm．micro—emulsifiedwithin3minandresolvedcompletelyin0．1mol／LHC1within10—15rain．KeyWords：silymarin；selfmicro--emulsification；pseudo--ternaryphasediagram
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