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Cholerny Spammer
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 Posted: Thu 4:24, 17 Mar 2011 Post subject: jimmy choo wedding shoes pxw lwu dar gct |
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Carvedilol Heart Failure Study of receptor mechanisms
In the development of new blood vessels around the capillaries of the process, are considered tumor development and metastasis of ..., of inhibition of angiogenesis inhibitors has become an important way to cancer therapy. Is well known that vascular endothelial cells constitute the main component of endothelial cell proliferation and extracellular matrix adhesion with the other steps are necessary for angiogenesis. Therefore, inhibition of endothelial cell apoptosis and promote survival of endothelial cells during angiogenesis is considered to be the basic mechanism of J, the recent discovery of a number of vascular endothelial growth factor can block apoptosis. On the contrary more and more evidence of angiogenesis inhibitors is that '4,[link widoczny dla zalogowanych], vascular endothelial cells can promote the degradation of tumor blood vessels, as with apoptosis of tumor cells,[link widoczny dla zalogowanych], can inhibit tumor growth and metastasis, thus improving cancer patients prognosis. The research group from the Chinese cobra venom separation and purification of a kind of molecular weight of about 8ku, isoelectric point 7.5 of the single active component, named CCVAF (ChinaCO-bravenomactivefactor) o previous studies have demonstrated that selective inhibition of endothelial CCVAF cells], inhibition of lung cancer cells induced endothelial cell migration J, and both inhibition of angiogenesis in vitro role of J, in order to further investigate the role of produce such functionwasinvestigated. Atthesametime, plasmanorepinephrineinnormalandheartfailuregroupwasmeasured. Results ① The ± dp / dt ... ofheartfailuregroupweresignificantlyreducedcomparedwiththoseofthenormalgroup, andthenorepinephrinelevelwasremarkablyhigherthanthatofthenormalgroup. ② Inheartfailuregroup, perfusedPRLonthebasisofISO, themaximumrateofleftventficularpressurerise (+ dp / dt) decreasedby40.37% ± 2.52%, themaxi-mumrateofleftventricularpressuredecrease (a dp / dt) reducedby41.36% ± 1.10%; perfusedCARonthebasisofISO, + @ / dt. decreasedby24.73% 4-3.60%, a dp/dtreducedby22.05% ± 1.27%. Thereweredifierencesbetweenthesetwogroups,[link widoczny dla zalogowanych], andthecardiacfunctionperfusedCARwasbetterthanPRL. ③ PerfusedCARinheartfailuregroup, + dp / dt ... increasedby41.57%-I-14.98%,[link widoczny dla zalogowanych], a dp / dt ... in-creasedby33.39%-I-6.41%: perfused133ARspecificblockerSR59230A,[link widoczny dla zalogowanych], + @ / dtmaxincreaseby45.75% ± 2. 64%, a dp / dt ... increasedby42.81% 4-9.62%. Therewerenodifierencesbetweenthesetwogroups. ConclusionAnotherreceptormechanismofCARinheartfailuremodelwasprobablyblockedby133AR. KeyWords: heartfailure; perfusionofisolatedheart; carvedilol; SR59230A; receptormechanism
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