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Malignant gliomas after three-dimensional conformal radiation therapy of 20 cases


Narrow focus is not less than 50% or more than 25% increase was observed 3 months after treatment, CT or MRI showed residual tumor shrink the tumor situation. 2 Results from the 3D-CRT 2.1 follow-up date, follow-up time as of February 2004, followed up a median period of 18 months (4 to 24 months), (1 case were no lost) follow-up rate of 100%. 2.2 The effect of the recent cases in this group 2O completed treatment programs,[link widoczny dla zalogowanych], treatment neurological symptoms were improved. According to 3 months after treatment,[link widoczny dla zalogowanych], CT or MRI to detect local efficacy evaluation: CR7 cases, PR9 cases, NC4 cases; was 80. O%, full 1-year survival in 19 cases, accounting for 95. O%, 2 years survival in 16 patients, accounting for 80. O%. 4 patients who died, 1 patient 6 months after treatment and died of local control, 3 patients were died of local recurrence after 1 year. 2.3 6 cases of adverse reactions in patients 2 to 8 weeks after treatment, headache or nausea, vomiting, CT or MRI, cerebral edema, the incidence of 30. O%, all patients were treated with dexamethasone and mannitol dehydration of 1 to 2 weeks after the improvement or remission. Which parts of the brain edema: 3 cases of frontal lobe,[link widoczny dla zalogowanych], parietal lobe in 2 cases, 1 case of temporal lobe. Found no cases of radiation brain injury. 3 to discuss the biological behavior of malignant gliomas is characterized by invasive growth, surgical resection is the main treatment,[link widoczny dla zalogowanych], but total removal is not easy and after surgery easy to relapse. Treatment of malignant gliomas with surgery alone 5-year survival rate of <25%, the majority of patients with highly malignant death in 2 years. Postoperative radiation therapy to eliminate residual prevent tumor recurrence and prolonged survival time, lower survival risk, so it is particularly important postoperative radiotherapy J. However, malignant glioma is a tumor sensitive to low radiation, and tumor lethal dose is the tolerance of normal brain tissue is difficult to dose, dose limits by conventional radiotherapy, conventional fractionated radiotherapy has long been the overall effect is disappointing. Mainly due to local control and tumor recurrence. 4 patients in this group is 2 years leading cause of death. Three-dimensional conformal radiation therapy using three-dimensional planning system implemented in the computer under the control of non-coplanar, multi-angle, Focused radiation, the treatment positioning accuracy, the tumor while receiving high dose, tumor margin dose of sharp decline, the high-dose region The dose distribution compared with the actual shape of the tumor region conformal. In as much as possible while protecting normal tissue region can increase tumor dose, lower side effects than conventional radiotherapy to improve the treatment of tumors gain ratio jJ. 3D. CRT can improve the radiation dose and target volume conformal capacity, can accept the high dose of normal brain tissue to reduce 30% ~ 50% E6]. Of patients with malignant gliomas after three-dimensional conformal radiation therapy, results showed that: the local control rate of 80. O%, 1,2 year survival rate was 95. O%, 80. O%, results are encouraging. And basic resistance in patients with few complications and found no increase in acute toxicity, suggesting that it may increase the dose in this largely to further improve the local control rate. [
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