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LPS induced fever in the course of the hypothalamus on body temperature and cAMP content of TRPV4, [Ca ^ 2 +] i concentration


Natural Science Foundation of China (No30770869); Hubei Provincial Department of Education funded projects focus on research (NoB200524007); Shiyan Municipal Science and Technology Research Grant (No2006ZD005) Author: Lau Ching Wan (1968 a), female, MA,[link widoczny dla zalogowanych], MD, deputy director of research directions: research and treatment of cardiovascular disease,[link widoczny dla zalogowanych], E-mail: judy95627 @ sohu. COB; Ren Yongsheng (1967 a), male, associate professor, research direction: the pathophysiology of cardiovascular active peptides, Tel: 07l9-8875312,[link widoczny dla zalogowanych], E-mail: ten-yongsheng @ 163con plasma IMD IMD levels and protein secretion compared with aortic increase in the sham group; ventricular muscle protein secreted IMD compared with sham group and the early reduction of shock; with the sham group and the comparison of early shock, the expression of aortic IMDmRNA decreased expression of ventricular IMDmRNA has increased. Conclusion of rat IMD in the pathophysiology of septic shock process is endogenous shock onset of protective substances. Key words: shock; hemodynamics; Intermedin sepsis, septic shock and multiple organ failure secondary to critically ill patients is a common cause of death. Early septic shock, the body in cardiac output and tissue perfusion increase in high-power type and the increase in high blood glucose metabolism in type state; shock when presented with advanced cardiac output and decreased tissue perfusion and low blood sugar low metabotropic performance ¨ J. The phenotypic changes in the mechanism of shock is not yet fully elucidated, has confirmed that a variety of neurohumoral factors and organize local factors involved in this process. Calcitonin (calcitonin), calcitonin gene-related peptide (cal-citoningene-relatedpeptide, CGRP),[link widoczny dla zalogowanych], adrenomedullin (adrenomedullin, ADM) and islet amyloid polypeptide (amylin) gene is highly homologous, is defined for the CGRP superfamily, which regulate the body's homeostasis play an important role in the pathogenesis of various cardiovascular diseases J. Recently, the U.S. and Japanese scholars and other scholars Takei Roh and other phylogenetic analysis using EffectsofTRPV4onLPS-inducedfever,[link widoczny dla zalogowanych], thecontentofcAMPandtheconcentrationof [Ca] iinrathypothalamusWANGLan-lan, WANGLe, CAOYu (DeptofPhysiology, ChinaMedicalUniversity, Shenyang110001, China) Abstract: AimToexploretheeffectofTRPV4inthermoregulation. MethodsWemadethefevetmodelwithlipopolvsaccharideinratandusedrutheniumred (RR) toinhibittheactivityofTRPV4tostudiedthecontentofTRPV4, cAMPandtheconcentrationoffCa] i. ResultGivenRRsolelvdecreasedthetemperatureComparedwithLPSgroup, theincreaseamplitudeofAT, camp, [Cah] ialldegradeinRR + LPSgroupAndthecontentofTRPV4arelessthancontrolgroup. Conclusion ④ TRPV4maypartiei-patethemaintenanceofnormothermia; ② Thefervers-eencewasimplementedbyactivatingTRPV4channeltoinducealargecalciuminfluxandthenincreasingthecontentofCAMP. Keywords: fever; TRPV4; LPS; [ca]; cAMP