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Anti-cancer drug PI kinase activity and tumor cell relationship


eU. Plxo ~ haUdylinos / tolkinas ~ isaetivedjnnr ~ mhranesdeerlbedfromeelIstreatedwjthepidermalgrowthfac. w & £, 1987 {84; 7513 ~ 75177DIrir ~ elrH. FtlI | eR. Chanin mouth Ilosplmtidylionsitolmem ~ l 【 smi ~ ocrda '. dwithgrowthsm the ofnormatandRom larvae mavirastramformcdJa kun n blind IqunilceiIs, threatening , 1977'97: 2978 ~ 208 | 8OIs ~ nJW. En | l | nc -cylinder phosphatklylinositolKinaseactivityisassociatedwitheariyslasesofhapateearclno ~ nsi = andDo-B/ocheca flail omm. 1985I32z969 ~ 9759BerriagemInosholli # dsandcpro] iteration · Dh coffee . 1987 ~ 907:33 ~ 45RelationshipofantitumordurgsandtumorcellmembranephoshPatidylinositolklnaseLIANGMou,[link widoczny dla zalogowanych], WU/3o. LIANGNian-Ci ( but ofRj spider f,[link widoczny dla zalogowanych], fat Biocl ~ raistey.ana, # ong threat dCN. /. ~ e, Z ~ fiaag524023) ABSTRACTEffectsofeightantitumordrugsoncellpro] iferationandee1] membranephosphatidylla ~ tol (PI) kinas ~ inhumanchron-icmyelogenousLeukemiaK Ⅻ 2cellswerestud-jed. Theresultsjndjcaredthat5 a f 】 urouraci1. methotrexate,[link widoczny dla zalogowanych], polymyxinB, homoharringtonineandvineristlnenotonlyinhibitedobviouslytheeel s0gignificant 】 】 】 proliferationbuta vdecreasedtheactivityofPIkinases. itsuggeststhatthe. 『 0lvin9 incubation Enlerpris ~ GroupMedicalandPharmaccutl song lRearchlnrt 【 ¨ f. Shenzhen5l8ii29decreas ~ ofPIkjnaseacjt] tyisoneofjnjt] an jsmofnuclea 】 】 】 processesthataffactthemetabo acid0lproteln-andtheninhibitcellprolifera-tion. onthecontrary,[link widoczny dla zalogowanych], adrlamycinthatobviouslyinhibitsKscellproliferation, sap'leasthiotepaandcytoxanthatactdirectlyonDNA, don'taf-factthePIkinaseactivitty, whichsuggeststhatthejrmechanismofantjtumorhasnorh 】 『 ] gtodowjththechangeofPIkinase, KEYWORDSantitumordurgs: myeloge-flOU ~ leukemia; phosI) I1atidylinosito] kinase; cc 】 ] proljferation