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Little knowledge about the mechanisms of atrial fibrillation and thinking


, ERP and the dispersion increase rate of induced atrial fibrillation and maintain long time. De in heart treatment,[link widoczny dla zalogowanych], although it can slow down the sinus rhythm, but atrial and pulmonary vein was significantly prolonged ERP, ERP and the dispersion decreases, the induced AF was significantly reduced. So that: stimulate the vagus nerve stem, heart, blood vessels within the fat pad and heart atrial plexus is the role of the sympathetic effect rather than the vagus effect. Atrial remodeling in the study of nerve distribution: Wasmund et al reported that the increase in sympathetic nerve activity associated with atrial fibrillation, the irregular ventricular fibrillation law is due to sympathetic overactivity, renin. Angiotensin. Aldosterone system (RAAS) related to the neuroendocrine system through the signal transduction pathways activated ion channels of myocardial cells and gap junctions between cells to reduce cell impedance and shorten the refractory period of myocardial cells. Therefore, the atrial muscle cells of the sympathetic and RAAS abnormal distribution of reconstruction activities,[link widoczny dla zalogowanych], may be triggered by the initial factor of focal discharge, which lead to atrial electrical remodeling and structural remodeling,[link widoczny dla zalogowanych], maintenance and development of the atrial fibrillation . Often used in clinical B-blockers and vascular converting enzyme inhibitors can effectively control some of paroxysmal atrial fibrillation, the incidence of atrial fibrillation is the sympathetic support of abnormal tension or tension can be a strong vagal reflex strengths after the sympathetic cause atrial fibrillation,[link widoczny dla zalogowanych], which will challenge the concept of vagal atrial fibrillation. Studies on the mechanism of atrial fibrillation over the years has precipitated a lot of new ideas, the author talked about in recent years, some knowledge of basic research. Physiological and pathological conditions the mechanism of atrial fibrillation is a complex multi-link, and can not be improved by a single electrical remodeling, structural remodeling in atrial fibrillation or nerve reconstruction to achieve the purpose of cure. Integrated to improve the electrical remodeling,[link widoczny dla zalogowanych], structural remodeling or reconstruction of treatment strategies nerve may be the basic idea of our treatment of atrial fibrillation.