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I-2190B immunosuppressant classification producing strain, fermentation and the crude extract inhibited the immune ...


Spike on the base color is not finished. In some training with the former based on the Yi Sheng pollution embroidered banner color, which is reported for the yellow color or the mattress edge of the hoe as described in a 2190 strain I and FK-5Z ~ producing strains should be classified as the same species, or even retain the original seedling number show strong courtyard. Named f port myhyprosco-p roundworm ssubsp. yalr. e. sliimaensls1-21902l-zlg0f wipe strain I-219O fermentation set in the days of winter slope (the main component of glucose per 1000ml of avian 10g, aspartic cable 0.5g, K = HPO = 0.5g, agar 12g, pH6.8 ~ 7.0) 8 ~ 1O days after training, transfer types of braided with 100ml of fermentation medium lf00ml_-~ angle the bottle, 28 ℃ for 72 hours rotating gallery as sowing the seeds of 5 species into the home with 800ml medium The angle of the bottle 5000ml ---, 28 ℃ reciprocating shaker culture, the determination of active samples taken at different time, a black fungus Aspergillus test. The main fermentation medium by 3 points is soluble starch, yeast powder 0.5 thousand, peanut cake powder, 0.6%, CaCO. 0.1, pH6.8 ~ 7. O fermentation can be measured 48 hours the activity of anti-Aspergillus niger, 98 hours to reach peak. 31-2190B crude extraction and separation of 1-21B0 bacteria fermentation liquid centrifugation of mycelium, the gate acetone soak, remove the moisture concentration of acetone, ethyl acetate with dark (EA) extraction,[link widoczny dla zalogowanych], the EA extract evaporated to remove solvent to Na, So 'Market after dehydration a silica gel chromatography, EA Sin Chung Yan, Guo marrow with B were collected, concentrated splashing into the water, bulk material 469 * reduce secondary silica column chromatography, liquid anti-black collection Qu germ activity was detected, except take the media,[link widoczny dla zalogowanych], dry goods received B's crude. Layer with the line of its crude rabbit in vivo inhibitory activity of acne. 4]-2190B bar products in vivo immunosuppressive effects of alcohol Cuan 1-219 water pulley braided ship small items, the saline concentration of rare cunning to relay Yan, intraperitoneal injection. Research back to the dose of ~ I-21)) 0B coarse grain of delayed-type mice induced by sheep red blood cell response and ultra-shovel red blood cell antibody production against sheep rinse suppression role, while the drug cyclosporine as the control comparison,[link widoczny dla zalogowanych], the results of 1 - 2190B crude delayed hypersensitivity in mice and anti-sheep erythrocyte antibody legitimate charges made by the strong performance of its role and dose-related, 4 ~ 5mg/kgL_2190B crude and 50rag/kg cyclosporine inhibition of the same effect. ■ 5 to discuss drug Cyclosporin power stretch as the immune system of the first temporary seat for organ transplantation Yan antibiotic transcripts, and take a good therapy to teach Nou, 1984 Fujisawa Pharmaceutical Company's Research aluminum glimpse of those who has found a screening holding generate Fl (_506 the generation of John House, Department of seedlings, separated flesh from a FK for a 5O6, FK - ~, FK-s25 ~ FK-523 The treatment drug Fen Fen Central dig good bacteria, drugs to lower role. We immunoreactive substances in the screening process, in 1990,[link widoczny dla zalogowanych], Sichuan Jiangxian document lance isolated a warm mountain kind of soil Streptomyces. The C NING Ti Kwan to take points in the silica gel Zhu Qi, B,[link widoczny dla zalogowanych], C --- a band, collecting B activity was measured with immunization and found that it has a good date delayed hypersensitivity in mice and anti-sheep red cell antibody classes , the role of strong lo saddle letter glass around Meng Su. is the separation from the components of a complete body has been chemically combined Yu Kam-g for the FK-520 [days. other components still under investigation ..