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Non-enzymatic glycation end products and diabetic kidney complications


37:1 O ~ 14. Coronavirus pneumonia recently with the U.S. Center for Disease Control and Prevention CDC laboratory scientists and researchers in Hong Kong said, SARS, Guangdong Province in China and the Southeast Asia and other regions of the . Most readers may be unfamiliar to the coronavirus, so here we briefly introduce the basic features of coronavirus that causes infection in the clinical features, diagnosis, treatment and prevention of some of the content. Coronaviruses are PNA virus. Coronavirus Coronavirus Coronavirus is a genus Coronaviridae families, whose members include the three groups. The first group, Canine coronavirus, coronavirus cats, cat infectious peritonitis virus, human coronavirus 229E, transmissible gastroenteritis virus; the second group, bovine coronavirus. Human coronavirus OC43, mouse hepatitis virus; third group includes infectious bronchitis virus, turkey coronavirus virus and rat coronavirus. These viruses, human coronavirus causes the common cold. Coronavirus virus particles are mostly round. Oval or slightly pleomorphic, diameter 60-220nln, rod-like surface protrusions over sparse, about 20nln. Negatively stained electron microscope photographs show the shape of the crown of virus particles, hence the name. Viral particles within the virus RNA and protein components from the core of lipid bilayers outside. This virus is not strong resistance to physical and chemical factors, 56 ~ C10 minutes to eliminate the infection; pH3, with ether, chloroform,[link widoczny dla zalogowanych], or UV treatment, it can be inactivated. Prevalence of coronavirus in the world. Infection in the temperate regions, mainly in the winter and spring. In the U.S.,[link widoczny dla zalogowanych], the two coronaviruses OC43 and 229E strains caused every 2 to 3 years a major epidemic. Strain 229E infection generally tend to spread throughout the United States, and OC43 strains limited to some local areas. Coronavirus infection by about half of those symptoms. Re-infection common, possibly because antibody levels rapidly decrease. Coronavirus respiratory tract infection by respiratory droplets. Coronavirus infection caused by human coronavirus 229E and the main one OC43. In the past that these viruses only the upper respiratory tract infection in children, mainly the common cold,[link widoczny dla zalogowanych], and the common cold patients 10% to 30% caused by a coronavirus. Coronavirus cause the common cold virus incubation period of 2 to 5 days course for 6 to 7 days. The main clinical manifestations include malaise, rhinitis, headache, sore throat and cough, may have fever, hoarseness, chest pain, etc., even can cause, 'bJL sudden onset of asthma, and adult chronic bronchitis worse. Volunteer abroad studies have shown that the virus in addition to the common cold in adults, can also cause asymptomatic infection. However, some foreign textbooks that coronaviruses can cause even serious lower respiratory tract infection. It has been observed that the Marine Corps Recruit coronavirus infection occurs in about 1 / 3 of cases of pneumonia and pleural reaction. For adults with chronic lung disease or asthma conducted six studies have shown that coronavirus infection and exacerbation of respiratory symptoms. Some of the suspected viral infection of patients,[link widoczny dla zalogowanych], including 14,000 pairs of double serum coronavirus antibodies, including virus and found that 30 patients with acute coronavirus OC43 infection, of which 8 cases (including 4 adults) with pneumonia , 3 of them as well as other viral infections. 4 patients had neurological symptoms, 1 patient had severe myocarditis. Thus, coronaviruses can cause severe in all age groups, and other lower respiratory tract infections diseases. Coronavirus infection in many laboratory diagnostic methods, including virus isolation, hemagglutination inhibition test, indirect ELISA,[link widoczny dla zalogowanych], RIA, and in recent years, the reverse transcription polymerase chain reaction RT-PCR and so on. According to WHO and U.S. CDC's latest report, Hong Kong and American scholars have already developed a test for the new coronavirus caused SARS antibody detection methods, and found some cases the antibody titers after infection continues to increase. PCR method can be used rapid amplification of specific nucleic acid sequence of the virus. Of coronavirus infection, there is no specific antiviral therapy, and coronavirus infection on antiretroviral therapy are rarely reported in the literature. There is a study conducted in volunteers showed that the coronavirus in use before or after the attack attack, intranasal use CtA interferon, compared with the control placebo, the incidence of colds can, the severity of symptoms and signs and virus replication is reduced. The researchers also suggest that the combination of interferon and antiviral drugs, may increase efficacy. (Right Juxiang Source: China Medical Tribune 2003-04-03)