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Variation of HBV post-transcriptional regulatory sequences of the biological significance of sites


Expression activity are subject to different degrees of inhibition , suggesting HPRE mutation on IFN-7 and inhibition of TNF-a is not obviously affected ; in the role of IFN-a mutant 1 and mutant 3 of the CAT activity was significantly decreased expression of the difference There were significant (P 0.05). Tip 2 mutant could escape the inhibitory effect of IFN-a , thus affecting the antiviral activity of WN-a play short , HPRE sequence variation may affect the inhibitory effect of cytokines on HPRE , HPRE mutant strains may be more favorable than the wild Avoid the inhibition of cytokines , which became the dominant strain , which results using PCR sequencing predominant strains of HBV infection is consistent .