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Dipyridamole 35 cases of allergic purpura Observation


Use, review once a week blood, urine and stool occult blood, in order to determine the therapeutic effect. 1.3 Clinical criteria markedly: 5 ~ 7 days treatment, no new rash appears 2 to 3 weeks, symptoms and signs completely disappeared without recurrence. Effective: 3 weeks after treatment purpura disappeared, the basic improvement in symptoms and kidney damage are only a few hematuria or proteinuria. Invalid: After 4 weeks skin purpura does not go away or recur, the original no kidney damage or kidney damage by a new original symptoms and signs are not improving or worsening. 2 22 results in the treatment group fell markedly effective l1 cases, the effective rate of 94%, and the course of treatment no new cases of kidney damage. 18 patients in the control group, markedly effective in 9 cases, the effective rate was 77%. Treatment by the new Central Plains without renal damage in 4 cases with kidney damage. Through statistical analysis,[link widoczny dla zalogowanych], the efficiency of the two groups was significant difference (Y2 = 4.2, P <005). Treatment group than the control group. 3 to discuss common allergic purpura in children, occurs in the etiology of school-age children infected (bacteria, viruses, parasites and mycoplasma), food, drug allergies, vaccinations, pollen, insect bites and so on. 7O patients suffering from this group account for a child by the Yi India, 48 cases in 1 to 3 weeks prior to the onset of upper respiratory infection, 68%, we think that infection is one of the important factors Benbingfasheng (between the two groups was not statistically difference). Its pathogenesis is not clear, I currently considered to be mediated by vasculitis, small vessel endothelial cells to damage, leading to platelet activation and platelet arachidonic acid metabolites in blood factors A. (TXA2) and endothelial cells, arachidonic acid metabolites of prostacyclin (P () imbalance, vascular contraction and platelet adhesion strongly increased and a series of pathological and physiological changes. Anaphylactoid purpura in children at home and abroad reported the presence of high immunization hypergammaglobulinemia, can plasma viscosity (which) increased, so the existence of acute hyperviscosity. so allergic purpura microcirculation drugs should be used early on. anticoagulant drugs dipyridamole inhibits platelet phosphodiesterase, the cAMP concentration and enhanced P (Xun. Thus, we use dipyridamole reduce the vascular inflammatory lesions caused by tissue damage, so that the condition was under control and reduce the relapse rate, and promote purpura disappeared. the treatment group, no one case of emerging kidney damage. while the control group in 4 cases. so there microcirculation to prevent kidney damage, to prevent the progress of renal damage. Only a few patients during the treatment there and the red, heart rate and other side effects were transient, no treatment. Use of dipyridamole treatment of allergic purpura is effective and worthy of clinical application.