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Schistosoma japonicum infection in ways different pathological damage of the liver


IJN Content of ± s × 10ng/ml comparison of irradiated l,: P> 0.05. #: P <0.05 2 Xu Huijuan. And so on. Schistosoma japonicum infection in ways different pathological damage to the liver to discuss the impact of ll93 13 Schistosomiasis is harmful to humans and animals, a zoonotic parasitic disease of people, adults mainly deposited production of eggs in the liver and colon wall organizations, granulomas and fibrosis caused by major diseases are schistosomiasis egg granuloma formation is a host of immune response to pathogenic factors, on the one hand by granulomatous reaction to eggs destroyed, and isolation and clear egg release of antigen, the body play a protective role; the other hand. Granulomatous destruction of the normal tissue reaction, the resulting eggs constantly connected to each other scar granuloma formation, the formation of fibrosis, damage to the body to produce results show that schistosomiasis infection in different ways and in different periods of infection are different effects on the body period of acute infection in the granulomatous reaction formed the most obvious, and as the development of course, to the chronic phase and late granuloma although reduced, but increased liver fibrosis is a group formed by multiple granulomatous infection and late in the chronic phase was significantly greater than the single infection group formed granuloma, due to the formation of a single infection to the chronic phase and late granuloma gradually by fibrous tissue repair, while the compensatory function of the liver gradually increased, however, repeated many times by the cercariae infection group attacks, there are more continuous release of soluble egg antigen,[link widoczny dla zalogowanych], the formation of granulomas responded more strongly, so granuloma volume was significantly reduced as a single infection of hyaluronic acid (HA) and viscosity protein (LN) is also a response to liver damage and an important indicator of liver fibrosis, especially in the chronic phase and late, HA can often be used to determine the activities of liver fibrosis and pathological changes in the fibrosis formation = A, collagen synthesis than degradation, so the response of serum fibrosis index in the hyaluronic acid has also increased, but the changes in mucin content of HA was not significant, this j reported in the literature are basically the same: Under normal circumstances, HA mainly by the liver endothelial cell uptake and decomposition, a small amount of HA can be excreted through the kidney, liver fibrosis, schistosomiasis is due to HA increased storage of fat cells increase in HA synthesis and proliferation of collagen vascular compression portal area, resulting in liver ~, tlf microcirculation, hepatic blood flow blocked, so that HA is not easy to reach the liver caused by reduced blood clearance HA; both liver endothelial cells on HA uptake capacity decreased decomposition, thus increasing blood HA. The increase of HA and LN of liver cells suggests this time is greater than the degradation of extracellular matrix synthesis, but this study also suggest that in the chronic phase and the late infection group repeatedly with the same amount of single infection group, the serum was significantly higher in the HA, because repeated infection, continue to have more soluble egg antigens and released more egg granuloma formation and fibrosis gradually, and in this process, cells enhanced synthesis of extracellular matrix, that is active liver fibrosis, which is often caused by liver damage and more serious. Therefore, recurrent infections and late chronic phase of schistosomiasis, in addition to insecticide treatment, there is a need for anti-fibrosis [
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