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An Bonuo of compound efficacy of mild to moderate hypertension


Effect in 2 cases,[link widoczny dla zalogowanych], total effective rate of 93%. Significant difference between the two groups (P <0.05). 2.2 the two groups after the end of treatment systolic blood pressure, diastolic blood pressure values, 24-hour average systolic blood pressure, mean diastolic blood pressure values, 24-hour SBP load and DBP load were significantly lower than before treatment, but the B group of blood pressure after treatment A group of key monitoring indicators and the indicators for monitoring blood pressure after treatment was significantly different than (P <0.05), Table 1. Zhejiang Medical 20O7 practical section on August l2 plastic table 1A Volume Khon group B before and after treatment comparison of changes in blood pressure (± s, mmHg) 259 before treatment P <O. 05, ), Table 2. Table 2 Comparison of biochemical indices before and after treatment in both groups (± s) 3 discussions angiotensin () is the regulation of blood pressure and the importance of water and salt metabolism of endocrine hormones, it is through the cell membrane with the target organ by the AT1 and ATI2 body binding to biological effects, and the AT1 receptor can cause vasoconstriction, cell proliferation, endothelin and catecholamine release, and the AT2 receptor can cause blood vessels to dilate and apoptosis. Irbesartan is Ang111 receptor antagonist (AT1RA), the drug selectively with the AT1 receptor, thereby blocking the various channels of all sources of Ang1T harmful effects, and does not affect the metabolism of bradykinin, no cough and other adverse reactions. AT】 by body was blocked, increased the Ang11 and AT2 receptor can further enhance its vasodilator effect and reverse vascular hypertrophy. low-dose antihypertensive effect of thiazide diuretics, mild, and combined with ACEI or ATIRA treat primary high blood pressure and reduce adverse reactions, hypertension treatment guidelines recommend combination therapy programs. The mechanisms are: diuretics increase sodium and water excretion and enhanced the antihypertensive effect of ACEI or AT1RA. Materson other study found that clinically recommended commonly used antihypertensive drugs, only 50% if used alone for a 60% blood pressure in hypertensive patients can be satisfied with the control. in the treatment of hypertension in the present application claims several small doses of the drug combination therapy _2J. The results show alone Irbesartan treatment of only 66% of patients satisfactory blood pressure control and Materson and other similar findings l3. However, after treatment compound An Bonuo total effective rate was 93%, the reaction decreased antihypertensive effect of the indicators are Bie Bei losartan group more obvious, Table Ming Bono Irbesartan is more effective than single buck. 24-hour ambulatory blood pressure monitoring results show that An Bonuo to reduce 24-hour average systolic blood pressure of patients, the average 24-hour systolic and diastolic blood pressure diastolic blood pressure load and the effect of load was significantly higher than irbesartan alone, indicating a relatively satisfactory antihypertensive effect. In addition, patients with mild to moderate essential hypertension in general out-patient treatment, safety, the greatest attention, In this study, patients in both groups before and after treatment liver function, uric acid, creatinine and potassium were no significant changes, also showed a well tolerated. In theory, ATIRA mild potassium can offset the dual role of grams of urea hydrogen emission potassium thiophene, the kind of long-term use in patients with compound electrolyte balance of the body should be reduced to a minimum. Although this study to be confirmed, but taking a short time, long-term medication needs to be verified.