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Clinical studies of berberine treatment of diabetes


The inflammation in 4 cases. Treatment: All patients were given strict diabetic diet (weight then calculate the total calories needed per day and its protein, fat, carbohydrate matter distribution in the amount of units, breakfast, lunch and dinner heat distribution is roughly 1 / 5, z / 5,[link widoczny dla zalogowanych],2 / 5) appropriate level of berberine and sugar before meals based on the amount of urine (us) and fasting blood bran (BS) level adjustment. Coptis cable 0,5 ~ 1.0 times. 3 times a day, Bs 136 or US (thirty) ~ () per 1,0 g. Maintenance dose per 0.5g; sugar fitness level 15 ~ 45mg / times. Three times daily. BS 13. 6 or US (thirty) ~ () for each 45rng, to maintain the amount of time] 5mg. Recorded once a week the symptoms, signs, fasting glucose, postprandial blood glucose 2h, 24h urine quantitatively. Blood pressure and ECG abnormalities daily review of blood pressure, electrocardiogram reviewed 2 times per week. Before and after treatment of liver and kidney function. Response Evaluation Criteria: ① ideal control: air dry moat blood glucose <6] mmo] / L. Postprandial 2h <7. Z2retool / L. 24h urine quantitative <; @ better control: Air Management glucose 7.22 <mmol / L, postprandial 2h <8.33mmol / L. Z4h urine quantitative <10g; ③ general control: fasting blood glucose <8.33mmo [/ L. Postprandial 2h <10mmo [/ L, Z4h urine quantitative <15g; @ poor control: those who not meet the above criteria. Results: Coptis orderly group: 63 cases of the ideal control, better control in 32 cases. General control in 6 cases, poorly controlled 1l down, the total effective rate was 90%; sugar level appropriate group: 67 cases of the ideal control. Better control of 33 cases. On behalf of the general control - in the District People's Hospital of Jining City) 67 patients were selected {duo methods ZZ4 people. Randomly divided into two groups (the results of berberine berberine girl effective treatment of diabetes funda 90%. And the deputy for the system down, down 8 poorly controlled, the total effective rate of 93%. Two patients were followed up six months after the .1 Z0 ~ 1a patients control good. continued use .76 cases of complex dietary glycemic control Erzhi up. then berberine treatment is still good results, 3 cases of gastritis Nan was forced to stop. poor management of all critically ill patients. and more than a cerebral infarction, pulmonary infection and other complications. In addition to the gastrointestinal tract reaction steps, no other adverse reactions. medication liver and renal function damage. Coptis cable group after treatment, 90% of cases the clinical symptoms disappeared, no low blood sugar to normal after glucose response appears, and in the l week, high blood pressure to normal blood pressure, coronary heart disease, arrhythmia patients showed significant improvement of their ECG. and sugar level appropriate group of patients although 93% of all symptoms disappeared, but patients with the hypertension, myocardial ischemia and arrhythmia before and after treatment show no improvement. 2 discussions berberine rhizome plants as buttercup the main alkaloid contained. Coptis bitter cold dampness, have the power Qingwei ney. often with other drugs Diabetes Treatment compatibility prescription form. Coptis tangled vessels reduce sympathetic activity, inhibition of adrenal function, so that gluconeogenesis, decomposition by-step, slow metabolism of insulin tangled. surrounding tissue sensitivity to insulin. berberine has been reported Turbulent hypoglycemic, anti-platelet aggregation. anti-arrhythmia, blood fat and blood pressure and so on; Chinese Academy of Medical Sciences Pharmaceutical Research Institute are also confirmed: both sulfonylureas and biguanides berberine characteristics of hypoglycemic drugs. Coptis not tangled the secretion of insulin release tangled. does not affect the liver cell membrane insulin receptor number and affinity. speculate the role of receptor effects may be. In this paper 112 cases of type 2 diabetic patients treated with berberine, the total efficiency of 90% , in addition to 3 down because of stomach trouble stopping, but I had no adverse reactions, and the merger of hypertension, coronary heart disease, arrhythmias also have a therapeutic effect. further proof of the hypoglycemic effect of Coptis known exactly, and the role of moderate and lasting. no serious side effects. no liver and kidney dysfunction. a common complication of diabetes have a good effect; other drug had no effect on normal blood sugar does not cause low blood sugar reactions, and low prices. is an ideal worthy of the drop sugar drugs, but should be noted that less effective treatment of severe patients. should be combined with other drugs. for type 2 diabetes. (date of 1998-10 received your samples a Z1) 67 ·