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Mitogen-activated protein kinase: a potential treatment of pathological pain new target for drug


: 1, aequorin and the ca furo-2 method or radioactive Changes. However, BAPTA had similar traditional high-water-soluble calcium complexing agent, can not cross the cell membrane, must be micro-injection into the cells, to study function of intracellular calcium caused great inconvenience to J, so Tsien acetyl oxygen and the other will be a BAPTA base (acetoxymethy1) reaction of four fat-methoxy-acetyl oxygen that BAPTA-AM. BAPTA-AM easy access to the cell while the cell without damage, while the release of BAPTA produce formaldehyde, experiments show that the effective dose range of BAPTA-AM did not release toxic formaldehyde produced. BAP-TA-AM is widely used in research and Ca L0Guo-wei (1.DeptofNeurology,[link widoczny dla zalogowanych], theAffiliatedHospitalofTaishanMedicalCollege, TaishanShandong271000, China; 2.InstituteforHypoxiaMedicine, CapitalMedicalUniversity, Beijing100069,[link widoczny dla zalogowanych], China) Abstract: Pathologicalpainorclinicalpainiscausedbytissueandnerveinjuries,[link widoczny dla zalogowanych], andisusuallychronicandmainlydividedin-toinflammatorypainandneuropathicpain. Pathologicalpainistypicallycharacterizedbyhyperalgesia (increasedresponsive-l'leSStonoxiousstimuli) andallodynia (painfulresponsestonor-mallyinnocuousstimuli). TheMAPKsareafamilyofevolution-allyconservedmoleculesthatplayacriticalroleincellsigna-ling,[link widoczny dla zalogowanych], consistingofextracellularsignal-regulatedkinase (ERK), p38,[link widoczny dla zalogowanych], andc-JunN-terminalkinase (JNK), whichplayanimpor-tantroleinneuralplasticityofpathologicalpain. InhibitionofMAPKsalleviatesinflammatorypainandneuropathicpainindif-ferentanimalmodels. ItiSveryimportanttostudytheinhibitionofMAPKsasatherapeuticapproachtotreatingpathologicalpain. AllthestudiessuggestthatMAPKsisapromisingthera-peutictargetforpathologicalpain. Keywords: MAPKs; pathologicalpain; inflammatorypain; neu-ropathicpain; MAPKsinhibitors