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Torasemide and furosemide effects on brain edema after stroke Comparative Study


Effects, in 1 hour to reach the peak plasma concentration, sodium excretion in the range of 2.5 ~ 20mg of the linear relationship between drug elimination half-life of 3.8 hours, and sustainable for 5 to 8 hours; torasemide loop acting on the medullary thick ascending limb segments of sodium excretion during diuresis are strong, but because of its anti-aldosterone effect of endogenous, that is able to inhibit the plasma aldosterone to its receptor, thus preserving potassium torasemide strong, long-term use will not cause hypokalemia, application security, which is not available in furosemide characteristics; torasemide not only significantly less than the amount of potassium in furosemide excretion,belstaff españa, serum magnesium, serum calcium no significant effect on the concentration,tory burch, but also for uric acid, glucose and lipids had no effect; from the metabolic pathway comparison, torasemide mainly from the liver and the total clearance rate of 8O, while the clearance rate of renal excretion only accounted for of 2O, and the major metabolite no activity, so the renal dysfunction half-life of the product has little effect,ghd italia, no accumulation of long-term, continuous use; its diuretic resistance is also very rare -5]. Therefore,uggs outlet rotterdam, efficacy or safety, whether from the for torasemide furosemide are more superior than the therapeutic value. The results also showed that mannitol combined brain edema torasemide treatment of stroke, its diuretic effect better than the control group and treatment were significantly increased efficiency and total efficiency, reducing the mortality and morbidity, adverse reactions during use, improve the patient's survival, quality of life. In short, torasemide in the treatment of acute cerebral vascular accident period, can collaborate with mannitol rapidly reduce intracranial pressure, cerebral edema, elimination of free radicals, improve cerebral hypoxia, is conducive to control the disease,mbt shoes italia, and promote the recovery of neurological function, improve clinical treatment and patient quality of life, and fewer adverse reactions, it is worth in the treatment of brain edema after stroke further application.