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All patients with malignant tumors of oral and maxillofacial TNF-α levels in saliva of the RIA


Child (TNF), and that activation of TNF in macrophages mainly by / produced by monocytes TNF-a factor not only to make such a tumor necrosis factor, the role of degradation,[link widoczny dla zalogowanych], and is involved in resistance to infection,[link widoczny dla zalogowanych], shock and multiple organ failure , cachexia and other pathological physiological processes , ② by TNF on the immune function of the regulation, promotion of T cells and other killer cells on tumor cell killing; ⑧ TNF effect on vascular endothelial cells, endothelial cells or lead to vascular dysfunction, the vascular injury and thrombosis, resulting in tumor tissue local vascular occlusion and bleeding, hypoxia necrosis.. In short a large number of studies, TNF-n shows good anti-tumor characteristics and various biological effects. Therefore, the close and effective monitoring of the exact level of TNF-a , and more attention. Some studies show that the state variety of diseases and tumors,[link widoczny dla zalogowanych], the serum TNF levels Balkwill et al reported a - 31 down from 32 normal sera detected only 1 down with TNF activity, the positive rate was 3 , 175 cases from 226 cancer patients serum, 114 cases with TNF activity. positive rate of 5o. with the normal group was significantly different than that. According to reports, the TNF-a gene transfected tumor cells as vaccines for clinical trials have begun. use of saliva as a simple clinical disease diagnosis or monitoring of non-invasive method. In this experiment, recombinant human TNF-n immune antiserum commercial quality, the use of high sensitivity and reproducibility radioimmunoassay (lower limit of the sensitivity 6fmol / m1), detection, TNF-a levels observed in the normal amount of facial cancer patients with oral saliva, serum changes. experimental tumors seen in normal group and a group of TNF content of whole saliva in the phase. than there was no significant difference . In this study, 5 cases of cancer were observed before and after operation in the whole saliva content of TNF-n changes were seen in 1 case t gingival cancer surgery was 3.41 times after surgery,[link widoczny dla zalogowanych], the other an inverted tongue cancer patients before surgery 2.04 times for the surgery, the other three cases are also different levels before surgery than after surgery (see table). But according to this set of data show that, although 5 down the whole saliva of patients before surgery were higher than TNF-n After surgery, walking down the observed standard deviation is too large, but no significant difference. Based on these preliminary results, showing the saliva levels of TNF-a and do not reflect the oral and maxillofacial malignant changes in patients with TNF-a. In addition According to the results of this study another 15 patients with cancer and serum TNF-levels in whole saliva compared to TNF-a levels significantly, indicating that TNF-a saliva content in the lower than serum. Therefore, integrated the Experiments on the findings,[link widoczny dla zalogowanych], we can consider that in the oral maxillary facial malignant state, the serum TNF-a were significantly higher than that of whole saliva, present in saliva instead of serum TNF a also not detected, it still can not top the face of oral cancer, as observed indicators. but fell ill in this experiment detected a limited number of whole saliva in the study was to detect TNF-a levels in order to explore the use of TNF-a saliva test as a cancer indicators for monitoring a lot of work still needed.
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