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Toxicological studies of Ganoderma lucidum Fuzheng granule


Time correlation, but also no dose-related, within the normal range of volatility changes. Administration of 13 weeks, male animals, dose of albumin, total protein, total bilirubin, Cl loading degree was significantly lower than the control group: administration of 26 weeks. Dose group of female animals, total bilirubin less than the control group. Low dose group of female animals less than the control group of creatine kinase: withdrawal 4 weeks dose group of female animals of total protein than the control group (Table 4). These changes, asked no relevance,[link widoczny dla zalogowanych], but also no dose-related, within the normal range of volatility changes. 2.2.4 Ganoderma Fuzheng particles on rat organ coefficient of continuous oral administration 13,26 weeks,[link widoczny dla zalogowanych], the femoral artery in each group were sacrificed 12,24, respectively, rats (male and female), necropsy and carefully Are there visible lesions observed after the rapid removal of the heart, liver, spleen, lung, kidney, adrenal gland, thymus, brain, testis, epididymis, uterus, ovary and other organs weighed and organ coefficient calculated (organ index: dirty control wet weight / body weight xl00). The results showed that administration of 13 weeks, the high dose group of female rats the liver organ coefficient is greater than the control group; 26 weeks, male rats in high dose group liver organ weight and organ coefficient is larger than the control group : withdrawal 4 weeks, the high dose group male rats the liver organ weight and organ coefficient is larger than the control group. 2.2.5 histological examination of the tissue in 10% neutral formalin-fixed. Conventional paraffin, HE staining by light microscopy. Dose group and the control group rat brain, heart, liver, spleen, lung, kidney, adrenal gland, thymus, testis, epididymis, uterus, ovaries and other organs of the anatomical location, shape, size, color, size, texture, surface and cut surface showed no obvious abnormalities. 3 Discussion of Ganoderma lucidum is a valuable medicine Fuzheng spore particle-based traditional Chinese medicine. Intended for the adjuvant treatment of malignant tumors. Ganoderma righting the acute toxicity and particle toxicity in rats long-term experiments show that mice with the greatest concentration, the maximum volume of one side of Ganoderma help 16.5L} one by one ~ a ~ August 2008 Volume 5, No. 23 Table 4 Ganoderma righting oral administration on blood particles biochemical indices of (+ j) of the comparison with the control group,[link widoczny dla zalogowanych], P <0.05. }} P (o.01 are fed grain VI services, day 2, the maximum tolerated dose is 20g/kg: Ganoderma centralizer particles (1.63 ~ 6.5lg/kg) 26 weeks of continuous oral administration, to agent group neutrophils, platelet count, mean hemoglobin and blood urea nitrogen,[link widoczny dla zalogowanych], alkaline phosphatase, albumin, total protein, total bilirubin and other indicators compared with the control group there was significant difference,[link widoczny dla zalogowanych], but when these changes Weijian Q relevance, but also no dose-related, within the normal range of volatility changes; gross necropsy and histological examination showed no pathological changes characteristic not observed in rats with Ganoderma righting characteristic particle toxicity has not observed that the delayed toxicity of particles for the clinical application of Ganoderma righting a toxicological basis. [
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