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Artificial mechanical valve replacement of infective endocarditis in patients with advanced


Hospitalized elderly patients before treatment, liver and kidney function tests were done, young and old in the treatment of patients with pulmonary tuberculosis, after a clinical observation shows that streptomycin, isoniazid, rifampin, pyrazinamide and so on liver kidney side effects, have similar metabolic and elimination capacity. The current anti-TB drugs Rifampicin is the drug of choice, it is mainly by the liver and liver microsomal enzymes of oxidative metabolism, with a strong induction of hepatic drug metabolizing enzyme, hepatic microsomal enzyme young people than old people, long-term use in the body pharmacokinetics of absorption, distribution, discharge the same with the elderly. Compound rifampicin, when the daily oral dosage 450rag. Both the young and the elderly. Have reached sufficient efficacy strength. Therefore, the long-term use of this drug, elderly patients should consider the appropriate dose adjustment, to avoid damage to liver function. Appropriate to reduce the amount of rifampicin, can achieve the effect. But also reduce drug side effects. According to the information reported: Adult tuberculosis with rifampicin 150mg, can maintain an effective antimicrobial concentration of 8 hours} When the dose increased to 450rag time. Can be maintained for 24 hours effective inhibitory concentration. High doses, can increase plasma concentrations and prolonged elimination time, on the liver and kidney damage. Although anti-tuberculosis drug rifampicin is preferred, it is mainly through hepatic portal vein, into the blood after oxidative metabolism by plasma concentration and liver microsomal enzyme activity related. A large number of long-term use of rifampicin, pyrazinamide can cause liver and kidney damage. Rifampicin is a hepatic microsomal enzyme inducers, long-term use will accelerate their metabolic rate. The maximum therapeutic dose. Maximum therapeutic concentrations. Can achieve more than the maximum inhibitory concentration, sufficient to achieve efficacy strength. When the effect is bad, should not blindly increased dose. Prevent damage to liver and kidney function should decrease rifampicin, the amount of imidacloprid howl amide. Can achieve the effect. And reduce toxicity. Patients had clinical symptoms of liver and kidney, the termination of rifampicin, the treatment of adjacent amide hydrochloride, exclude the existence of liver and kidney toxicity vitamin lK. If {Dl Mao flap kidney infection treatment. (Edit. CHANGDE) ultrasonic aerosol inhalation Zhichuan I ~ Li Yuhua Li, a Chinese ● _-_'- I,, - a, Hui Central Hospital from the Hill 6, r in our hospital from February 1994 to 4 months will be diagnosed as asthmatic pneumonia by hospitalized children l3 · randomly divided into two groups and the control group of 50 cases. The observation group with vitamin K, ultrasonic atomizing inhalation therapy get better results. These are as follows: 1 1.1 The sex and age of clinical data: the observation group 28 males. Female 22 Li; ~ 6,[link widoczny dla zalogowanych], r on 22 cases, ~ l l9-year-old cases, 6 down to 3 years old,> 3 years and 3 cut out the control group 32 male and female l8 cases of patients 6 months 3o, ~ l1 { patients, 5 patients 3 years old,> 3 years, 1 case. 1.2 Symptoms and signs: two groups of patients hospitalized within 3 days of onset of more than 8o. With asthma are coughing, fever and nasal inflammatory, three depressions sign. , R of the hard dry rales. With heart failure were observed 5 cases in the control group l1.3 peripheral blood tests: white blood cell count below 10 × 10L fHf group account for more than 6o. . 1.4 The chest x-ray films: observation group, the shadow of cases of right lower lung small pieces, small pieces under the shadow of both lungs l4 cases, the rest is increased lung markings. Control group, the shadow of the right lower lung small pieces IO cases, both lungs under the shadow transfer sheet 1 l6 cases. The rest is increased lung markings. 2 treatment of 2.1 treatment; two groups were made ultrasonic atomizing inhalation 2 times / day. Every 15 minutes. Riga-a 20ml saline ACT 3 ~ 5rag / times in the observation group atomization plus vitamin K. Children 6 months to F 8rag / times. 6 ~ l2 months, children 12rag / times. 1-year-old with seven 16rag / times. Control group, dexamethasone spray solution. 61 months of age children 5nag / times. 6 ~ l2 months, children 7.5rag / times. . 1 or more children 10rag / times. Two other treatment and care are the same. 2.2 Efficacy Evaluation: ultrasonic atomizing inhalation of two groups of patients after treatment decreased respiratory rate of 10 beats / min or less. Three depressions significantly reduced symptoms, decreased lung dry sound alarms for effective inhalation 10 minutes after the end of the markedly alleviate wheezing; 3O minutes in relief for the effective, effective in the sum of the total valid and effective, and 30 minutes without remission Invalid 2.3 Treatment Results: Table. Zhichuan total effective observation on the effects of 44 cases (8. Effective control group, 28 cases (56. Statistical analysis X. = 12.7. P <O.01. There was a significant difference. Observation group 10 minutes after inhalation quiet sleep in 19 cases. 3 Discussion Asthmatic wheezing in children the main symptoms of pneumonia, a common one used in clinical ultrasound Zhichuan inhalation therapy is also widely used. get better results. now intramuscular vitamin K, intravenous' injection treatment providers