Forum pracy nad projektem wskrzeszenia The Forge

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... _3467
HBV intrauterine infection of hepatitis B vaccination of children with vaccine failure and its receptor IL-2? ...


Ag immune tolerance. The results showed that the infection had no response officials there are not only HB-sAg specific stimulation of expression of mIL-2R under the less, while its production capacity there IL_2 exception. HBsAg in the PHA stimulation and stimulation, no response to intrauterine infection in children in the secretion of IL-2 PBMC was significantly lower than responsive children and normal children group, while the normal response group and no significant difference between groups of children. Children in the intrauterine infection, IL-2 secretion and receptor expression may be due to the low level of the following factors: (1) in patients with hepatitis B in peripheral blood mononuclear cells in the presence HBVDNA], HBV can affect the function of PBMC led to reduced ability to secrete IL-2, IL 2R expression of a lack of {(2) official in lymphocyte subsets in children infected with the proportion of disorder, CD4 + decreased, CD8 + increased ridicule, inhibit the increase in T-cells} (3) may exist the cytokine network of the disorder, the serum may also be some inhibitory factor; (4) As the antigen presenting cells (monocytes) and IL-1 is IL-2 production of the important factors, both of dysfunction can be lead to IL-2 and its receptor dysfunction, both the existence of obstacles to be studied further. This study showed that no response to intrauterine infection in children under the existence of HBsAg stimulated IL-2 secretion and expression of the low level. Therefore, adding exogenous IL-2 is expected to reverse the immune failure. MeuerSC so ineffective against hepatitis B vaccination in patients with uremia, while injection of hepatitis B vaccine were given 2.5 × 10U of intramuscular injection of IL-2, 6 / 10 patients who achieved a protective antibody in the control group only] / 6 produced antibodies. However, Jungers, etc.] on 52 not respond to hepatitis B vaccination in patients with chronic uremia DeS2 containing recombinant hepatitis B vaccine + IL-2 (Imu) local subcutaneous injection, compared with placebo, have not found a 2 m promote the role of antibody production. Thus, local application of IL-2 alone can not solve the problem of immune unresponsive. Because the local application of a 2 m there is a short half-life, the role of the shortcomings quickly disappeared, and only by adding exogenous IL-2 IL-2 receptor can not solve the problem of low response also involves other non-immune to the virus mutation IL A 2 and its receptor system other than the problem.