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Clinical observation of the cooling effect of ibuprofen


After cooling effect of ibuprofen changes in the past 4 years, we have used ibuprofen tablets (Henan Topfond Pharmaceutical Co) to cool down, observe the degree of temperature drop, to guide the clinical use of drugs to prevent blindness. Are as follows. 1 1.1 General information clinical data 1O, 2002 to August 2006 May we observed 144 cases of fever in patients with the cooling effect of ibuprofen tablets,[link widoczny dla zalogowanych], 106 patients were male; 38 female. The oldest 55 years old,[link widoczny dla zalogowanych], minimum 18 years. Since the 43 cases of acute leukemia; 6 cases of Staphylococcus sepsis Yan; malignant lymphoma, 8 cases; l2 cases of metastatic adenocarcinoma; 3O cases of upper respiratory tract infection; 23 cases of urinary tract infection; intestinal infection, 12 cases; 1O cases of fever of unknown origin . 1.2 Methods for the majority of patients with recurrent fever during hospitalization phenomenon, in the same patients, the use of self-control law, that the first heat with oral ibuprofen 0.20g as the observation group, a total of 144 patients; given a second heat intramuscular injection of compound aminopyrine 2.0lIll as the control group, after the temperature change observed 60.0rain. 1.3 Statistical-IS measurement data, said two groups were compared by U test. All data handled by the SAS software. 2 results of the two groups before treatment and 2.1 after treatment, the average temperature 60.0rain said by-IS for statistical analysis, the U test,[link widoczny dla zalogowanych], medication prior to U = 1.823,[link widoczny dla zalogowanych], P> 0.05, no significant differences; after treatment,[link widoczny dla zalogowanych], U = 2.701, P <0. O1, the difference was statistically significant, see Table 1. Table 1, body temperature before and after treatment comparison groups () body temperature of 2.2 lift the two groups after treatment 60.0min case temperature observed no change in 1 patient group, the remaining 143 cases were decreased body temperature, body temperature drop up to 6. I ~ C (down from 41.5 ~ C 35.4 ~ C); l9 cases of the control group no change in body temperature, body temperature drop up to 4 ~ C (down from 40.4 ~ C 36.4 ~ C), 7 cases and increased temperature, in Table 2. Table 2 compared two groups of 927 degree body lift plant +. + '+. +, {{K-+ exchange of experience a +. + A +3 to discuss this key observation ibuprofen tablets 0.20g relationship with body temperature, age 18-5O years old, weighing 36 ~ 67kg. And use of antipyretic effect of drug dose is not completely proportional to its antipyretic effect may be related to individual sensitivity to the drug was directly proportional to the individual more sensitive to drugs, the greater the temperature drop. As the small number of observed cases, the drug dose and individual sensitivity issues remain to be further studied. Phenylalanine ibuprofen as a non-steroidal anti-inflammatory analgesic, antipyretic role as one of its role, the patient's body temperature can reduce the fever, the treatment dose, within the central nervous system by inhibiting prostaglandin synthesis, enhance cooling process (such as the expansion of surface blood vessels, increased sweating), the sky antipyretic effect. Can be used repeatedly, no drug resistance, the maximum dose of each drug up to 0.60g, the daily dosage of up to 2.40g, the safety range. decrease up to 6.1 ℃. Therefore, we must patiently explained to patients before treatment and close observation after treatment (particularly after treatment 6omin within) without sweating, thirst, exhaustion and other phenomena of wet limbs in order to a timely manner. of leukemia and tumors from the antipyretic effect of persistent high fever sure. this group of 63 from leukemia and cancer cases, accounting for 43.7%, before treatment at 39.5 ~ C above body temperature, average temperature 40.1 ℃, the average body temperature after administration 60.0rain 37.4 ~ C. orally easy to absorb, to avoid the repeated subcutaneous injection of antipyretic agent that causes bleeding. However, this drug only as symptomatic treatment during heating, cooling should also be active in helping doctors find causes, treatment of primary disease.