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Acute organophosphorus poisoning rescue doses of atropine (analysis of 154 cases)


O. 6 The majority of patients resistant to 2 h to 4 days, all symptoms disappeared atropine total 8O ~ 1lOmg. Table 1 mild, moderate amount of atropine to the Arab-Israeli goods Qi hee dose atropine after the holding of the number of days the amount of healing (mh) (n'w'h) 2.2 heavy dose of atropine poisoning (Table 2, 3) 74 cases of severe poisoning, there 1O cases of poisoning due to improper overweight or gastric lavage soon die,[link widoczny dla zalogowanych], so people are not out of range of doses of atropine 2.2.1 To the rescue dose of atropine from the table 3, see, I severe poisoning, the poisoning and Ⅱ group and the group without atropine poisoning the time of emergence, of the rescue dose of atropine induced showed a very significant among the differences. Table 2 The results show that the rescue dose of one too, although atropinization appeared earlier, but easy to B} from atropine poisoning. Atropine poisoning rescue dose group listed is effective, but unsafe; group is not listed in the rescue dose of poison to be effective and safe dose. Can also be seen from Table 2, Ⅱ type of intoxication is not the total rescue group (1008 ± 49) rag than the total amount of toxic rescue group (794 ± 3 rag is too, between the two was very significant difference (P < 0.001). This shows that the total atropine poisoning and emergency treatment is not necessarily a positive correlation between the main and the amount of drug per unit time that the rate of drug-related, therefore, choose a safe and effective dose of atropine, mainly to determine the unit of time drug dose. 22.2 after atropine atropine to maintain inventory of 3 shows the amount of atropine poisoning is atropine group to maintain the cause of atropine poisoning occurs after the average amount; maintenance dose is not toxic group refers to atropine after the patients of the average amount of time awake. Maintenance dose of the two groups was very significant difference. Atropine poisoning group I and Ⅱ, respectively, for the maintenance of the rescue dose of 74% and 60%; not poisoning group I and Ⅱ was l8% and 24% in Table 2 of the dose and atropine induced Schedule 3, after atropine based maintenance ■ 【rh In other words, atropine poisoning group average decrease of 26% and 4o%; not poisoned group, the average reduction of 82% and 78%. Obviously, atropine poisoning caused by atropine than r and the time of the unit size of the given dose, but also after atropine reduction of speed. 3 to discuss the rescue of acute organophosphate poisoning remains a major problem in emergency medicine. Although the conduct of hemoperfusion for organophosphate poisoning in the emergency of new paths, but the effects are hard to sure. Therefore, the difficulty of Taiwan is still reasonable dose of atropine. A reasonable dose of the Wei River, is both effective and safe dose of the fork of the clinical and atropine poisoning atropine is sometimes difficult to draw the line between; last too doses of atropine, organophosphate poisoning will increase due to serious complications, such as respiratory failure ...; with atropine used in the individual and so on. This first aid often difficult to grasp the reasonable doses, it causes frequent reports of atropine poisoning. To this end, we analyzed 154 cases of acute organophosphorus poisoning atropine dose in order to find effective and safe use of the drug's general law. 3.1 The first assessment to determine the extent of poisoning atropine dose, you should first of the severity of poisoning there is a rough estimate. The severity of organophosphate poisoning and toxic poisons, toxic dose, poisoning relations between both methods. According to the clinical manifestations and complications appear to be divided into mild, moderate and severe. Severe poisoning can be divided according to whether the serious complications I, Ⅱ two types. Determined according to the different degrees of poisoning atropine dose and maintenance dose of the rescue and drug delivery approach. 3.2 Prevention of atropine poisoning is a reasonable selection of key clinical doses of atropine of organophosphorus poisoning on the emergency use of atropine dose, there is a This report on the increasing number of atropine poisoning. For this reason, cases of poisoning, especially in severe poisoning, the dose of atropine should be emphasized that both effective and safe. The key lies in two aspects: First, determine the cause of the reasonable dose of atropine. This data suggest that severe poisoning, I-to (25.91 ± 234) ~ h, Ⅱ-type to (63.86 ± 2.40) anti-h is appropriate. Followed by maintenance dose after atropine based I-to (5.24 ± 2.92) ~ g / h, Ⅱ type to <1546 ± 3.50) h is appropriate. Only in this way, both the rational use of the rescue dose, but also chose to maintain a reasonable amount of opportunities for atropine poisoning can be greatly reduced. Clinically, signs of atropine poisoning, the author's experience that the Once clinical atropine poisoning should be immediately reduced or stopped under the condition of atropine, to be used with caution after atropine poisoning atropine to correct