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Changes in coagulation of pregnant women in labor and its clinical significance


Automatically calculate the INR value. Statistical Methods 1.4 t (or t) test. 2 The results showed that pregnant women in labor PT, INR, and 1Tr significantly decreased compared with the control group (P 0.05) (Table 1). Table 1 and the control group of pregnant women in labor coagulation test results compared (± s) △ t ​​= 3 as discussed in the normal physiological conditions, coagulation and anticoagulation in dynamic balance, promote and inhibit blood clotting material interactions and constraints, constitute the clotting mechanism of self-control and regulation. In the normal late pregnancy, the body is in a hypercoagulable state, this state will help prevent excessive bleeding during childbirth,[link widoczny dla zalogowanych], and provide the material basis for the post-partum bleeding. However, once this obstetric hypercoagulability induced factors exist, it tends to develop into disseminated intravascular coagulation (DIC). Screening coagulation tests are the main types of hemorrhagic disease diagnostic index, P, r reflects the plasma prothrombin, fibrinogen and factor V, Ⅶ, x the level is to check the extrinsic coagulation system are normal indicators. Due to different sources,[link widoczny dla zalogowanych], different methods of tissue preparation of thromboplastin greater impact on the results, so the use of INR to unify the judge the results. APTI 'reflects the intrinsic coagulation system, coagulation factor Ⅷ, Ⅸ, Ⅻ, Ⅺ, the common pathway of thrombin, fibrinogen and factor V, x the level of inspection is the most commonly used endogenous coagulation system sensitive screening test. The results showed that pregnant women in labor PT, INR, compared with the control group was significantly shorter, and the results compared with control group APTF was no significant difference, consistent with previous research reports, and reports with Hooser River and other inconsistencies. FIB concentration was pregnant,[link widoczny dla zalogowanych], and their contents starting from 3 weeks gestation increased, peaking at term from non-pregnant average time of 2 ~ 4g / L in late pregnancy to the 4 ~ 6g / L. Our results show that FIB test results of pregnant women in labor was significantly higher, consistent with Xu Chengwei such reports. FIB increased partly because the mother's own needs,[link widoczny dla zalogowanych], for delivery to increase the consumption of the synthesis, on the other hand the reduction of tissue plasminogen, fibrinolytic activity decreased. During pregnancy, especially late clotting factor increased in varying degrees, and anticoagulant function, and so that the internal environment of pregnant women anticoagulant mechanism of coagulation of a change in the blood hypercoagulability. Rrr shorter term pregnant women, partly because the reduction in consumption of plasminogen as the relative increase, resulting in blood increased fibrinogen degradation products; the other hand, coagulation factor Ⅻ late pregnancy reduction is difficult to non-soluble fibrin formation,[link widoczny dla zalogowanych], and fibrin monomer complex easily hydrolyzed by plasmin, resulting in an increase in fibrinogen degradation products, so 1_r time was significantly shortened. Normal pregnancy the body to produce a series of physiological changes, moderate coagulation is a physiological protection from excessive bleeding, but it should be taken to avoid the occurrence of fibrinolysis J. The high maternal blood coagulation state during delivery of a number of trigger factors, the easily lead to tissue injury, tissue thromboplastin clotting properties of enzymes into the blood, consume a large amount of clotting factor, causing coagulation dysfunction, risk of induced DIC and therefore there is maternal bleeding during delivery, should attach great importance to, and remove DIC may, more indicators of the dynamic observation of regular, to reduce and prevent DIC or thrombotic complications. [
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