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连续加速超

 
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lin91957
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PostPosted: Fri 19:56, 18 Mar 2011    Post subject: 连续加速超

连续加速超分割放射治疗和后程加速超分割放射治疗食管癌近期疗效比较
示,CAHF与IAIAP治疗食管癌的近期疗效优于文献报道的常规放射治疗。但2组间的局部控制率和生存率无显著性差异。CAHF虽然比LCAF放射治疗进一步缩短了治疗时间,但并未能进一步提高生存率,这说明除了肿瘤细胞的加速再增殖以外,还有一些其他因素影响着放射治疗疗效,需要我们进一步的研究和探讨。加速超分割放射治疗由于缩短了治疗时间,加剧了早反应组织的损伤,因此,急性放射性食管炎、气管炎发生率明显增高_7]。在CAHF组,急性放射性食管炎,尤其是Ⅲ、Ⅳ度严重的急性食管炎明显增多,反应高峰时间提前至放射治疗开始后第3周。LCAF方案Ⅲ、Ⅳ度食管炎较少,以I度和Ⅱ度反应居多,反应高峰期多在放疗即将结束时或放疗结束后,经消炎等对症治疗后很快就消失。由于我们对加速超分割放射治疗的急性放射反应有充分的认识,在放射治疗开始后积极给予患者支持和对症处理,所以2种治疗方法的急性放射反应对整个疗程的完成影响不大。CAHF和脚治疗食管癌已经取得了较为满意的疗效,但如何进一步降低急、慢性毒副作用,将成为食管癌加速超分割放射治疗的重要研究内容。此外,由于三维适形调强技术在给予靶体积以充足剂量的同时,能够最大限度地保护周围正常组织,也将逐渐在食管癌加速超分割放射治疗中广泛使用Is,9l
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